In this manuscript we review the state of cardiac cell modelling in the context of international
initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim …

Cellular signaling operates in a noisy environment shaped by low molecular concentrations
and cellular heterogeneity. For calcium release through intracellular channels–one of the …

Calcium puffs are local transient Ca 2+ releases from internal Ca 2+ stores such as the
endoplasmic reticulum or the sarcoplasmic reticulum. Such release occurs through a cluster …

Abstract Intracellular calcium ([Ca 2+] i) oscillation is a fundamental signaling response of
cartilage cells under mechanical loading or osmotic stress. Chondrocytes are usually …

Using deterministic-stochastic simulations we show that for intracellular calcium puffs the
mixing assumption for reactants does not hold within clusters of receptor channels …

Abstract Inositol 1, 4, 5-trisphosphate (IP 3)-induced Ca 2+ signaling is a second messenger
system used by almost all eukaryotic cells. Recent research demonstrated randomness of …

Modeling plays a crucial role in Systems Biology in order to provide a system-level
understanding of biological systems. With the rapid development of systems biology …

With recent advances in structural biology, including experimental techniques and deep
learning-enabled high-precision structure predictions, molecular dynamics methods that …

Puffs and sparks are localized intracellular Ca 2+ elevations that arise from the cooperative
activity of Ca 2+-regulated inositol 1, 4, 5-trisphosphate receptors and ryanodine receptors …

The spatiotemporal dynamics of elementary Ca2+ release events, such as “blips” and “puffs”
shapes the hierarchal Ca2+ signaling in many cell types. Despite being the building blocks …