Surface modification of lipid-based nanoparticles
There is a growing interest in the development of lipid-based nanocarriers for multiple
purposes, including the recent increase of these nanocarriers as vaccine components …
purposes, including the recent increase of these nanocarriers as vaccine components …
The global hearing therapeutic pipeline: 2021
B Isherwood, AC Gonçalves, R Cousins, R Holme - Drug discovery today, 2022 - Elsevier
Hearing loss is a serious condition affecting more than 1.5 billion people globally. Many
affected people benefit from the use of devices, such as hearing aids, but these do not …
affected people benefit from the use of devices, such as hearing aids, but these do not …
New molecular therapies for the treatment of hearing loss
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …
loss is characterized by degeneration of key structures of the sensory pathway in the …
A state-of-the-art analysis of pharmacological delivery and artificial intelligence techniques for inner ear disease treatment
W Li, N Zheng, Q Zhou, MS Alqahtani… - Environmental …, 2023 - Elsevier
Over the last several decades, both the academic and therapeutic fields have seen
significant progress in the delivery of drugs to the inner ear due to recent delivery methods …
significant progress in the delivery of drugs to the inner ear due to recent delivery methods …
[HTML][HTML] Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss
K Xu, B Xu, J Gu, X Wang, D Yu, Y Chen - Theranostics, 2023 - ncbi.nlm.nih.gov
Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …
Predicting atrophy of the cochlear stria vascularis from the shape of the threshold audiogram
Several lines of evidence have suggested that steeply sloping audiometric losses are
caused by hair cell degeneration, while flat audiometric losses are caused by strial atrophy …
caused by hair cell degeneration, while flat audiometric losses are caused by strial atrophy …
[HTML][HTML] Towards the optimization of drug delivery to the cochlear apex: influence of polymer and drug selection in biodegradable intracochlear implants
There is growing need for new drug delivery systems for intracochlear application of drugs to
effectively treat inner ear disorders. In this study, we describe the development and …
effectively treat inner ear disorders. In this study, we describe the development and …
[HTML][HTML] A new auditory algorithm in stock market prediction on oil and gas sector in Nigerian stock exchange
Stock market prediction is the process of forecasting future prices of stocks. Stock market
prediction is a challenging process as a result of uncertainties that influence the market …
prediction is a challenging process as a result of uncertainties that influence the market …
Combined AAV-mediated gene replacement therapy improves auditory function in a mouse model of human DFNB42 deafness
K Isgrig, AX Cartagena-Rivera, HJ Wang, M Grati… - Molecular Therapy, 2023 - cell.com
Hearing loss is a common disorder affecting nearly 20% of the world's population. Recently,
studies have shown that inner ear gene therapy can improve auditory function in several …
studies have shown that inner ear gene therapy can improve auditory function in several …
Investigation of inner ear drug delivery with a cochlear catheter in piglets as a representative model for human cochlear pharmacokinetics
E Yildiz, AJ Gadenstaetter, M Gerlitz… - Frontiers in …, 2023 - frontiersin.org
Hearing impairment is the most common sensory disorder in humans, and yet hardly any
medications are licensed for the treatment of inner ear pathologies. Intricate …
medications are licensed for the treatment of inner ear pathologies. Intricate …