It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

The eight enzymes responsible for the biosynthesis of the three branched-chain amino acids
(l-isoleucine, l-leucine, and l-valine) were identified decades ago using classical genetic …

Phthiocerol dimycocerosates (DIM) are major virulence factors of Mycobacterium
tuberculosis (Mtb), in particular during the early step of infection when bacilli encounter their …

Auxotrophic mutants of Mycobacterium tuberculosis have been proposed as new vaccine
candidates. We have analyzed the virulence and vaccine potential of M. tuberculosis strains …

Attenuated mutants of Mycobacterium tuberculosis represent potential vaccine candidates
for the prevention of tuberculosis. It is known that auxotrophs of a variety of bacteria are …

With almost a dozen vaccine candidates in clinical trials, tuberculosis (TB) research and
development is finally reaping the first fruits of its labors. Vaccine candidates in clinical trials …

Drug resistance of pathogens has necessitated the identification of novel targets for
antibiotics. Thiamin (vitamin B1) is an essential cofactor for all organisms in its active form …

The branched-chain amino acids (BCAAs [Ile, Leu, and Val]) represent important nutrients in
bacterial physiology, with roles that range from supporting protein synthesis to signaling and …

Francisella novicida is a facultative intracellular pathogen capable of growing in
macrophages. A spontaneous mutant of F. novicida defective for growth in macrophages …