The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …

The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle
progression during mitosis with the state of chromosome attachment to the mitotic spindle …

Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome
stability by delaying cell division until accurate chromosome segregation can be …

In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

The spindle checkpoint ensures proper chromosome segregation during cell division.
Unravelling checkpoint signalling has been a long-standing challenge owing to the …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

The genomic stability of all organisms depends on the precise partition of chromosomes to
daughter cells. The spindle assembly checkpoint (SAC) senses unattached kinetochores …