Linking discoveries, mechanisms, and technologies to develop a clearer perspective on plant long noncoding RNAs
Long noncoding RNAs (lncRNAs) are a large and diverse class of genes in eukaryotic
genomes that contribute to a variety of regulatory processes. Functionally characterized …
genomes that contribute to a variety of regulatory processes. Functionally characterized …
Challenges and advances towards the rational design of microalgal synthetic promoters in Chlamydomonas reinhardtii
Microalgae hold enormous potential to provide a safe and sustainable source of high-value
compounds, acting as carbon-fixing biofactories that could help to mitigate rapidly …
compounds, acting as carbon-fixing biofactories that could help to mitigate rapidly …
A promoter-level mammalian expression atlas
Nature, 2014 - nature.com
Regulated transcription controls the diversity, developmental pathways and spatial
organization of the hundreds of cell types that make up a mammal. Using single-molecule …
organization of the hundreds of cell types that make up a mammal. Using single-molecule …
Gateways to the FANTOM5 promoter level mammalian expression atlas
M Lizio, J Harshbarger, H Shimoji, J Severin… - Genome biology, 2015 - Springer
The FANTOM5 project investigates transcription initiation activities in more than 1,000
human and mouse primary cells, cell lines and tissues using CAGE. Based on manual …
human and mouse primary cells, cell lines and tissues using CAGE. Based on manual …
DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts
Immunotherapies targeting cancer-specific neoantigens have revolutionized the treatment of
cancer patients. Recent evidence suggests that epigenetic therapies synergize with …
cancer patients. Recent evidence suggests that epigenetic therapies synergize with …
A comprehensive mouse transcriptomic BodyMap across 17 tissues by RNA-seq
The mouse has been widely used as a model organism for studying human diseases and for
evaluating drug safety and efficacy. Many diseases and drug effects exhibit tissue specificity …
evaluating drug safety and efficacy. Many diseases and drug effects exhibit tissue specificity …
Sequence basis of transcription initiation in the human genome
Transcription initiation is a process that is essential to ensuring the proper function of any
gene, yet we still lack a unified understanding of sequence patterns and rules that explain …
gene, yet we still lack a unified understanding of sequence patterns and rules that explain …
Bone marrow adipocytes facilitate fatty acid oxidation activating AMPK and a transcriptional network supporting survival of acute monocytic leukemia cells
Y Tabe, S Yamamoto, K Saitoh, K Sekihara, N Monma… - Cancer research, 2017 - AACR
Leukemia cells in the bone marrow must meet the biochemical demands of increased cell
proliferation and also survive by continually adapting to fluctuations in nutrient and oxygen …
proliferation and also survive by continually adapting to fluctuations in nutrient and oxygen …
Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition
K Saito, Q Zhang, H Yang, K Yamatani, T Ai… - Blood …, 2021 - ashpublications.org
Acute myeloid leukemia (AML) cells are highly dependent on oxidative phosphorylation
(OxPhos) for survival, and they continually adapt to fluctuations in nutrient and oxygen …
(OxPhos) for survival, and they continually adapt to fluctuations in nutrient and oxygen …
Alternative promoters in CpG depleted regions are prevalently associated with epigenetic misregulation of liver cancer transcriptomes
C Nepal, JB Andersen - Nature Communications, 2023 - nature.com
Transcriptional regulation is commonly governed by alternative promoters. However, the
regulatory architecture in alternative and reference promoters, and how they differ, remains …
regulatory architecture in alternative and reference promoters, and how they differ, remains …