Introduction Immune-checkpoint inhibitors (ICIs) have emerged as a core pillar of cancer
therapy as single agents or in combination regimens both in adults and children …

As one of the most abundant stromal cells, fibroblasts are primarily responsible for the
production and remodeling of the extracellular matrix. Traditionally, fibroblasts have been …

Angiogenesis, the formation of the new blood vessels from pre-existing vasculature, is an
essential process occurring under both normal and pathological conditions, such as …

Background The contribution of the tumor microenvironment and extracellular matrix to the
aggressive biology of Gastric Cancer (GC) has been recently characterized; however, the …

Psoriasis is a complex autoimmune skin condition with a significant genetic component. It
causes skin inflammation and is characterized by flaky, silvery reddish spots that can worsen …

Abstract Aims To evaluate BM-MSCs and their extracellular vesicles (EVs) preconditioned
with hypoxia or normoxia in experimental pulmonary arterial hypertension (PAH). Main …

While ovarian tissue cryopreservation (OTC) is an important fertility preservation option, it
has its limitations. Improving OTC and ovarian tissue transplantation (OTT) must include …

Research question What is the relationship between ATG8 and integrin α4β1, Talin-1, and
Treg cell differentiation, and the effects on endometriosis (EMS)? Design First, the …

Lymphatic vessels (LyVs), responsible for fluid, solute, and immune cell homeostasis in the
body, are closely associated with the adjacent extracellular matrix (ECM) molecules whose …

Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by occlusion of
pulmonary arteries by organized blood clots and occlusive vascular remodeling. Recent …