Impact of zinc transport mechanisms on embryonic and brain development

J Willekens, LW Runnels - Nutrients, 2022 - mdpi.com
The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn
flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence …

In-silico approaches to detect inhibitors of the human severe acute respiratory syndrome coronavirus envelope protein ion channel

MK Gupta, S Vemula, R Donde, G Gouda… - Journal of …, 2021 - Taylor & Francis
Recent outbreak of Coronavirus disease (COVID-19) pandemic around the world is
associated with 'severe acute respiratory syndrome'(SARS-CoV2) in humans. SARS-CoV2 …

Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (Mpro) of SARS-CoV-2 and inhibit its activity

V Kumar, JK Dhanjal, SC Kaul, R Wadhwa… - Journal of …, 2021 - Taylor & Francis
The recent novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2/2019-nCoV) has caused a large number of deaths around the globe. There is an …

Neuroblastoma: an updated review on biology and treatment

S Mallepalli, MK Gupta, R Vadde - Current drug metabolism, 2019 - ingentaconnect.com
Background: Neuroblastoma (NB) is the second leading extracranial solid tumors of early
childhood and clinically characterized by the presence of round, small, monomorphic cells …

TIGER: The gene expression regulatory variation landscape of human pancreatic islets

L Alonso, A Piron, I Morán, M Guindo-Martínez… - Cell reports, 2021 - cell.com
Genome-wide association studies (GWASs) identified hundreds of signals associated with
type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have …

SLC30A8 gene polymorphism rs13266634 associated with increased risk for developing type 2 diabetes mellitus in Jordanian population

S Mashal, M Khanfar, S Al-Khalayfa, L Srour, L Mustafa… - Gene, 2021 - Elsevier
Background Several genome-wide association studies (GWAS) have identified the single
nucleotide polymorphism (SNP) rs13266634 in the Solute carrier family 30 member 8 …

Computational characterization of structural and functional roles of DREB1A, DREB1B and DREB1C in enhancing cold tolerance in rice plant

R Donde, MK Gupta, G Gouda, J Kumar, R Vadde… - Amino acids, 2019 - Springer
Rice serves as the major food for almost half of the world population. Because of its origin in
the tropical and subtropical area, rice is more sensitive towards cold stress. Three homologs …

Docking study of chloroquine and hydroxychloroquine interaction with RNA binding domain of nucleocapsid phospho-protein – an in silico insight into the …

M Amin, G Abbas - Journal of Biomolecular Structure and …, 2021 - Taylor & Francis
Recent outbreak of novel Coronavirus disease () pandemic around the world is associated
with severe acute respiratory syndrome. The death toll associated with the pandemic is …

Computational approach towards understanding structural and functional role of cytokinin oxidase/dehydrogenase 2 (CKX2) in enhancing grain yield in rice plant

G Gouda, MK Gupta, R Donde, J Kumar… - Journal of …, 2020 - Taylor & Francis
Cytokinin oxidase/dehydrogenase (CKX) is the only known enzyme associated with
irreversible degradation of cytokinins in plants. CKX2 contains flavin adenine dinucleotide …

Curcumin-a novel therapeutic agent in the prevention of colorectal cancer

MK Gupta, R Vadde, V Sarojamma - Current drug metabolism, 2019 - ingentaconnect.com
Background: Colorectal cancer is the third important cause of cancer-associated deaths
across the world. Hence, there is an urgent need for understanding the complete …