Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …

The liver plays a key role in maintaining energy homeostasis by sensing and responding to
changes in nutrient status under various metabolic conditions. Recently highlighted as a …

Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-
cell proliferation and diabetes progression made it a research spotlight. Recently, the …

The liver plays a critical role in several metabolic pathways, including the regulation of
glucose and lipid metabolism. Non-alcoholic fatty liver disease (NAFLD), the most common …

Context: Angiopoietin-like protein 8 (ANGPTL8)/betatrophin is a secreted protein initially
involved in β-cell replication. Recent data in humans and mice models suggest that …

Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide
range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin …

Betatrophin (angiopoietin-like protein 8 (ANGPTL8)) is a hormone that was recently
discovered in the human liver. Multiple homologous sequences have been detected in …

Background Betatrophin has been recently reported to play a role in glucose homeostasis
by inducing beta-cell proliferation in mice. However, studies in human are inconsistent. As a …

The metabolism of triglycerides (TGs) is regulated, among others, by the lipoprotein lipase
(LPL) that hydrolyses the TGs on endothelial cells. In turn, LPL is inhibited by the ANGPTLs …

Background and aims Betatrophin, also known as angiopoietin-like protein 8 (ANGPTL8) or
lipasin, is a nutritionally-regulated mammalian-specific protein secreted by the liver and …