Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

Macrophages are the most important innate immune cells in humans. They are almost
ubiquitous in peripheral tissues with a large variety of different mechanical milieus …

Arterial Vascular smooth muscle cells (VSMCs) play a central role in the onset and
progression of atherosclerosis. Upon exposure to pathological stimuli, they can take on …

Pulmonary hypertension (PH) is a life-threatening cardiopulmonary disease characterized
by pulmonary vascular remodeling. Excessive growth and migration of pulmonary artery …

Poly L-lactic acid (PLLA) fillers stimulate collagen synthesis by activating various immune
cells and fibroblasts. Piezo1, an ion channel, responds to mechanical stimuli, including …

BACKGROUND: Computational modeling indicated that pathological high shear stress
(HSS; 100 dyn/cm2) is generated in pulmonary arteries (PAs; 100–500 µm) in congenital …

Fibrosis could happen in every organ, leading to organic malfunction and even organ
failure, which poses a serious threat to global health. Early treatment of fibrosis has been …

Mechanical force is the basis of cardiovascular development, homeostasis, and diseases.
The perception and response of mechanical force by the cardiovascular system are crucial …

Inspired by the well-known phenomenon of stretch-induced airway dilation in normal lungs
and the emerging stretch-responsive Piezo1 channels that can be chemically activated by …

BACKGROUND: STIM1 (stromal interaction molecule 1) regulates store-operated calcium
entry and is involved in pulmonary artery vasoconstriction and pulmonary artery smooth …