Triptolide, a compound isolated from a Chinese medicinal herb, possesses potent antitumor,
immunosuppressive, and anti-inflammatory properties, but is clinically limited due to its poor …

Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

NF-κB transcription factors are critical regulators of innate and adaptive immunity and major
mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant …

A common feature of many solid tumors is low oxygen conditions due to inadequate blood
supply. Hypoxia induces hypoxia inducible factor (HIF) stabilization and downstream …

Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with
the malignancy of various cancers. Signal transduction and activation of ZEB1 play …

Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

Simple Summary Given the importance of the epithelial-to-mesenchymal transition in tumor
progression and the pivotal role of ZEB1 as a transcriptional repressor during this process …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Acidosis characterizes the microenvironment of most solid tumors and is considered a new
hallmark of cancer. It is mainly caused by both “aerobic” and “anaerobic” glycolysis of …

Epithelial–mesenchymal transition (EMT) is a fundamental process that occurs during
embryogenesis and tissue repair. However, EMT can be hijacked by malignant cells, where …