Retinal ischemia is a common cause of visual impairment and blindness. At the cellular
level, ischemic retinal injury consists of a self-reinforcing destructive cascade involving …

Zinc is a life‐sustaining trace element, serving structural, catalytic, and regulatory roles in
cellular biology. It is required for normal mammalian brain development and physiology …

Management of glaucoma is directed at the control of intraocular pressure (IOP), yet it is
recognized now that increased IOP is just an important risk factor in glaucoma. Therapy that …

In addition to its familiar role as a component of metalloproteins, zinc is also sequestered in
the presynaptic vesicles of a specialized type of neurons calledzinc-containing'neurons …

Excessive zinc influx may contribute to neuronal death after certain insults, including
transient global ischemia. In light of evidence that levels of intracellular free Zn2+ associated …

In certain brain regions, extracellular zinc concentrations can rise precipitously as intense
neuronal activity releases large amounts of zinc from the nerve terminals. Although zinc …

Zinc complex of L-carnosine (L-CAZ; generic name Polaprezinc) is the first drug for oral
administration in which zinc plays an essential role. L-CAZ was approved as an anti-ulcer …

Earning tenure at an academic institution and running a steeplechase race successfully
have a lot in common. Both require extensive training before the event begins, both involve …

Experimental evidence exists to suggest that zinc can have positive and negative effects on
the physiology of cells depending on the 'local'concentration, localisation (extracellular vs …

Intracellular free Zn 2+ is elevated in a variety of pathological conditions, including ischemia-
reperfusion injury and Alzheimer's disease. Impairment of mitochondrial respiration is also …