Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …

Although mutations in mitochondrial-associated genes are linked to inflammation and
susceptibility to infection, their mechanistic contributions to immune outcomes remain ill …

Recent genome-wide association studies have linked common variants in the human
genome to Parkinson's disease (PD) risk. Here we show that the consequences of variants …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Studies of Parkinson's disease (PD) have been hindered by lack of access to affected
human dopaminergic (DA) neurons. Here, we report generation of induced pluripotent stem …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of …

Parkinson's disease (PD) is the second most common neurodegenerative disorder that is
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic …

Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …

Abstract Parkinson's disease (PD), like many common age-related conditions, has been
recognized to have a substantial genetic component. Multiple lines of evidence suggest that …