The development of solid-phase peptide synthesis in the early 1960s and recombinant DNA
technology in the early 1970s boosted the scientific interest of utilizing proteins and peptides …

Regulation of pulsatile secretion of growth hormone (GH) relies on hypothalamic neuronal
loops, major transmitters involved in their operation are growth hormone releasing hormone …

Cultured pituitary somatotrophs release growth hormone in response to spontaneous Ca2+
entry through voltage-gated calcium channels (VGCCs) that is governed by plateau-bursting …

CD20 is a transmembrane protein that functions as a Ca 2+-permeable cation channel
(Bubien, JK, Zhou, LJ, Bell, PD, Frizzel, RA, and Tedder, TF (1993) J. Cell Biol. 121, 1121 …

The secretion of GH from pituitary somatotrophs is mainly regulated by alterations in the
levels of intracellular free Ca 2+ concentrations ([Ca 2+] i) that depend on the influx of Ca 2+ …

In endocrine/neuroendocrine tissues, excitability of secretory cells is patterned by the
repertoire of ion channels and there is clear evidence that extracellular sodium (Na+) ions …

The classic view for hypothalamic regulation of anterior pituitary (AP) hormone secretion
holds that release of each AP hormone is controlled specifically by a corresponding …

The existence of cells storing and secreting two different anterior pituitary (AP) hormones
(polyhormonal cells) or responding to several hypothalamic releasing hormones (HRHs) …

Most electrical and ionic properties of anterior pituitary cells are common to all pituitary cell
types; only gonadotropes exhibit a few cell specific features. Under basal conditions, the …

We have studied the effects of gluta‐mate receptor agonists on the cytosolic Ca2+ concen‐
tration ([Ca2+] i) of single rat anterior pituitary (AP) cells. Ionotropic (NMDA and …