Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …

Angiogenesis is a critical step in the progression of almost all human malignancies and
some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective …

The decline of oxygen tension in the tissues below the physiological demand leads to the
hypoxic adaptive response. This physiological consequence enables cells to recover from …

MicroRNAs (miRNAs), a class of small noncoding RNA molecules, have been recognized as
key post-transcriptional regulators associated with a multitude of human diseases. Global …

With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we
witness the RNAi therapy field reaching a critical turning point, when further improvements in …

Angiogenesis is required in cancer, including gynecological cancers, for the growth of
primary tumors and secondary metastases. Development of anti-angiogenesis therapy in …

Since time immemorial, human beings have sought natural medications for treatment of
various diseases. Weighty evidence demonstrates the use of chemical methodologies for …

Non-coding RNAs are functional RNA molecules comprising the majority of human
transcriptome. Only about 1.5% of the human genome is transcribed into messenger RNAs …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor
prognosis due to early metastasis, low diagnostic rates at early stages, and resistance to …

Deregulated angiogenesis has been identified as a key contributor in a number of
pathological conditions including cancer. It is a complex process, which involves highly …