Unwinding the role of the CMG helicase in inborn errors of immunity

NC Guilz, YO Ahn, S Seo, EM Mace - Journal of Clinical Immunology, 2023 - Springer
Inborn errors of immunity (IEI) occur as the result of inherited monogenic variants that affect
human immune function and lead to immunological disease [1]. More than 500 individual …

The replicative helicase CMG is required for the divergence of cell fates during asymmetric cell division in vivo

N Memar, R Sherrard, A Sethi, CL Fernandez… - Nature …, 2024 - nature.com
We report that the eukaryotic replicative helicase CMG (Cdc45-MCM-GINS) is required for
differential gene expression in cells produced by asymmetric cell divisions in C. elegans. We …

PAX5 and circ1857 affected DLBCL progression and B‐cell proliferation through regulating GINS1

T Wang, Z Chen, C Li, W Zhang, W Huang… - Cancer …, 2023 - Wiley Online Library
PAX5, a member of the paired box gene family of transcription factors, is a B‐cell‐specific
activator protein that plays important roles during B lymphopoiesis. Two putative PAX5 …

OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer …

W Zhu, C Wu, Z Liu, SM Zhao, J Huang - Cell Communication and …, 2024 - Springer
Background Colon cancer is one of the most prevalent tumors in the digestive tract, and its
stemness feature significantly contribute to chemoresistance, promote the epithelial …

[HTML][HTML] Roles of DSCC1 and GINS1 in gastric cancer

S Hou, J Zhang, X Chi, X Li, Q Zhang, C Kang, H Shan - Medicine, 2023 - journals.lww.com
Gastric carcinoma is a common malignant tumor originating from gastric mucosal epithelium.
However, role of DS-cell cycle-dependent protein 1 (DSCC1) and GINS1 in gastric …

Replication stress in activated human NK cells induces sensitivity to apoptosis

NC Guilz, YO Ahn, H Fatima, LA Pedroza… - The Journal of …, 2024 - journals.aai.org
NK cells are innate immune effectors that kill virally infected or malignant cells. NK cell
deficiency (NKD) occurs when NK cell development or function is impaired and variants in …

[HTML][HTML] Testis transcriptomic analyses reveal the effects of an algae feed on sperm quality in Senegalese sole during the breeding season

F Félix, CR de Magalhaes, C Marrero-Alemán… - Aquaculture, 2025 - Elsevier
The usage of dietary algae antioxidants to improve fish reproduction is under-explored,
especially in terms of the male reproductive system. In this experiment, 6% of a blended …

[HTML][HTML] Complementary biomarkers of computed tomography for diagnostic grading of gastric cancer: DSCC1 and GINS1

Y Zhu, S Hou, C Kang - Aging (Albany NY), 2024 - ncbi.nlm.nih.gov
Objective: Computed tomography (CT) is an important tool for grading gastric cancer. Gastric
cancer typically originates from epithelial cells of gastric mucosa. However, complementary …

[HTML][HTML] Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues

KL Cerveny, H Bronstein, O Hagen… - Micropublication …, 2021 - ncbi.nlm.nih.gov
Cell behaviors such as survival, proliferation, and death are governed by a multitude of
cues, both intrinsic and extrinsic. To test whether a wild-type environment could encourage …