Common causes of hearing loss in humans-exposure to loud noise or ototoxic drugs and
aging-often damage sensory hair cells, reflected as elevated thresholds on the clinical …

The classic view of sensorineural hearing loss has been that the primary damage targets are
hair cells and that auditory nerve loss is typically secondary to hair cell degeneration …

The cannabinoid receptor CB2 is predominately expressed in the immune system, and
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …

The noise-induced and age-related loss of synaptic connections between auditory-nerve
fibers and cochlear hair cells is well-established from histopathology in several mammalian …

Summary Cannabinoid receptor 1 (CB 1) is the principal target of Δ 9-tetrahydrocannabinol
(THC), a psychoactive chemical from Cannabis sativa with a wide range of therapeutic …

Recent animal work has suggested that cochlear synapses are more vulnerable than hair
cells in both noise-induced and age-related hearing loss. This synaptopathy is invisible in …

Overexposure to intense sound can cause temporary or permanent hearing loss.
Postexposure recovery of threshold sensitivity has been assumed to indicate reversal of …

Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

Animal studies suggest that cochlear nerve degeneration precedes sensory cell
degeneration in both noise-induced hearing loss (NIHL) and age-related hearing loss …

In acquired sensorineural hearing loss, such as that produced by noise or aging, there can
be massive loss of the synaptic connections between cochlear sensory cells and primary …