Progressive supranuclear palsy (PSP), previously believed to be a common cause of
atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes …

ABSTRACT PSP is a pathologically defined neurodegenerative tauopathy with a variety of
clinical presentations including typical Richardson's syndrome and other variant PSP …

Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap
across etiologies, yet it is crucial for formulating early, personalized management strategies …

The syndromes caused by frontotemporal lobar degeneration have highly heterogeneous
and overlapping clinical features. There has been great progress in the refinement of clinical …

Importance Atypical parkinsonian syndromes (APS), including progressive supranuclear
palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be …

Frontotemporal lobar degeneration with tau (FTLD-tau) is a group of tauopathies that
underlie∼ 50% of FTLD cases. Identification of genetic risk variants related to …

Apathy and impulsivity are common and disabling consequences of frontotemporal lobar
degeneration. They cause substantial carer distress, but their aetiology remains elusive …

Importance Basket-design clinical trials that allow investigation of treatment effects on
different clinical syndromes that share the same molecular pathophysiology have not …

Although the diagnosis of dementia still is primarily based on clinical criteria, neuroimaging
is playing an increasingly important role. This is in large part due to advances in techniques …

Diffusion tensor imaging (DTI) allows measuring fractional anisotropy and similar
microstructural indices of the brain white matter. Lower than normal fractional anisotropy as …