Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

Cancer metastasis is facilitated by cell–cell interactions between cancer cells and
endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and …

There is a growing body of evidence suggesting that alterations in the adhesion properties
of neoplastic cells endow them with an invasive and migratory phenotype. Indeed, changes …

Background—Noninvasive imaging of adhesion molecules such as vascular cell adhesion
molecule-1 (VCAM-1) may identify early stages of inflammation in atherosclerosis. We …

Inflammation and cancer metastasis are associated with extravasation of leukocytes or
tumor cells from blood into tissue. Such movement is believed to follow a coordinated and …

Colorectal cancer is a serious health problem, a challenge for research, and a model for
studying the molecular mechanisms involved in its development. According to its incidence …

The liver is host to many metastatic cancers, particularly colorectal cancer, for which the last
2 decades have seen major advances in diagnosis and treatment. The liver is a vital organ …

1. Fonsatti E, Altomonte M, Coral S, Cattarossi I, Nicotra MR, Gasparollo A, Natali PG, Maio
M. 1997. Tumour-derived interleukin 1α (IL-1α) up-regulates the release of soluble …

Background: E4599 was a phase II/phase III trial, in which 878 patients with advanced non–
small cell lung cancer were randomized to carboplatin+ paclitaxel (PC arm) or PC+ …

Background Breast cancer is a notable cause of cancer-related death in women worldwide.
Metastasis to distant organs is responsible for~ 90% of this death. Breast cells convert to …