insights on current FDA-approved monoclonal antibodies against Ebola virus infection
O Tshiani Mbaya, P Mukumbayi… - Frontiers in immunology, 2021 - frontiersin.org
The unprecedented 2013-2016 West Africa Ebola outbreak accelerated several medical
countermeasures (MCMs) against Ebola virus disease (EVD). Several investigational …
countermeasures (MCMs) against Ebola virus disease (EVD). Several investigational …
Human antibodies for viral infections
JE Crowe Jr - Annual review of immunology, 2022 - annualreviews.org
Antibodies have been used to prevent or treat viral infections since the nineteenth century,
but the full potential to use passive immunization for infectious diseases has yet to be …
but the full potential to use passive immunization for infectious diseases has yet to be …
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies
C Wang, R van Haperen, J Gutiérrez-Álvarez… - Nature …, 2021 - nature.com
The coronavirus spike glycoprotein, located on the virion surface, is the key mediator of cell
entry and the focus for development of protective antibodies and vaccines. Structural studies …
entry and the focus for development of protective antibodies and vaccines. Structural studies …
Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
I Widjaja, C Wang, R van Haperen… - Emerging microbes & …, 2019 - Taylor & Francis
ABSTRACT The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic
virus that causes severe and often fatal respiratory disease in humans. Efforts to develop …
virus that causes severe and often fatal respiratory disease in humans. Efforts to develop …
Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody
E Mittler, A Serris, ES Esterman, C Florez… - Science translational …, 2023 - science.org
Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved
vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody …
vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody …
Analysis of a therapeutic antibody cocktail reveals determinants for cooperative and broad ebolavirus neutralization
Structural principles underlying the composition of protective antiviral monoclonal antibody
(mAb) cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a …
(mAb) cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a …
Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection
Passive administration of monoclonal antibodies (mAbs) is a promising therapeutic
approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have …
approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have …
Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses
Several ebolaviruses cause outbreaks of severe disease. Vaccines and monoclonal
antibody cocktails are available to treat Ebola virus (EBOV) infections, but not Sudan virus …
antibody cocktails are available to treat Ebola virus (EBOV) infections, but not Sudan virus …
Antibody-dependent enhancement of Ebola virus infection by human antibodies isolated from survivors
Some monoclonal antibodies (mAbs) recovered from survivors of filovirus infections can
protect against infection. It is currently unknown whether natural infection also induces some …
protect against infection. It is currently unknown whether natural infection also induces some …
Ebola vaccine–induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects
Although substantial progress has been made with Ebola virus (EBOV) vaccine measures,
the immune correlates of vaccine-mediated protection remain uncertain. Here, five mucosal …
the immune correlates of vaccine-mediated protection remain uncertain. Here, five mucosal …