There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …

Rationale: The transverse tubule (T-tubule) system is the ultrastructural substrate for
excitation–contraction coupling in ventricular myocytes; T-tubule disorganization and loss …

Cell type-specific transcriptional differences between brain tissues from donors with
Alzheimer's disease (AD) and unaffected controls have been well documented, but few …

Kv2. 1 exhibits two distinct forms of localization patterns on the neuronal plasma membrane:
One population is freely diffusive and regulates electrical activity via voltage-dependent K+ …

Background—Excitation-contraction coupling in striated muscle requires proper
communication of plasmalemmal voltage-activated Ca2+ channels and Ca2+ release …

Membrane contact sites (MCSs), where the membranes of two organelles are closely
apposed, are regions where small molecules such as lipids or calcium are exchanged …

SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple
signaling and disease related pathways with a broad diversity of reported substrates. Here …

Objectives: This study sought to study the role of junctophilin-2 (JPH2) in atrial fibrillation
(AF). Background: JPH2 is believed to have an important role in sarcoplasmic reticulum (SR) …

Membrane contact sites (MCS) are close appositions between two organelles that facilitate
both signaling and the passage of ions and lipids from one cellular compartment to another …