Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

M Aldunate, D Srbinovski, AC Hearps… - Frontiers in …, 2015 - frontiersin.org
Lactic acid and short chain fatty acids (SCFAs) produced by vaginal microbiota have
reported antimicrobial and immune modulatory activities indicating their potential as …

Mass spectrometry-based proteomics for pre-eclampsia and preterm birth

KP Law, TL Han, C Tong, PN Baker - International journal of molecular …, 2015 - mdpi.com
Pregnancy-related complications such as pre-eclampsia and preterm birth now represent a
notable burden of adverse health. Pre-eclampsia is a hypertensive disorder unique to …

Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term

P Mittal, R Romero, AL Tarca, J Gonzalez, S Draghici… - 2010 - degruyter.com
Aims: To characterize the transcriptome of human myometrium during spontaneous labor at
term. Methods: Myometrium was obtained from women with (n= 19) and without labor (n …

Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery

R Romero, S Mazaki-Tovi, E Vaisbuch… - The journal of …, 2010 - Taylor & Francis
Objective. Biomarkers for preterm labor (PTL) and delivery can be discovered through the
analysis of the transcriptome (transcriptomics) and protein composition (proteomics) …

Impact of prenatal disorders on the metabolic profile of second trimester amniotic fluid: a nuclear magnetic resonance metabonomic study

G Graca, IF Duarte, AS Barros… - Journal of proteome …, 2010 - ACS Publications
This paper describes a metabonomic study of prenatal disorders using nuclear magnetic
resonance (NMR) spectroscopy of amniotic fluid (AF) collected in the second trimester of …

[PDF][PDF] Sensitive detection of native proteins using extractive electrospray ionization mass spectrometry

H Chen, S Yang, M Li, B Hu, J Li… - Angewandte Chemie …, 2010 - zpsys.ecut.edu.cn
Protein analysis provides abundant information crucial to understanding mechanisms and
giving insight into life on the molecular level. Because of its unparalleled sensitivity and …

Identification and quantification of preterm birth biomarkers in human cervicovaginal fluid by liquid chromatography/tandem mass spectrometry

SJ Shah, KH Yu, V Sangar, SI Parry… - Journal of Proteome …, 2009 - ACS Publications
Spontaneous preterm birth (PTB) before 37 completed weeks of gestation resulting from
preterm labor (PTL) is a leading contributor of perinatal morbidity and mortality. Early …

Proteomics mapping of cord blood identifies haptoglobin “switch-on” pattern as biomarker of early-onset neonatal sepsis in preterm newborns

CS Buhimschi, V Bhandari, AT Dulay, UA Nayeri… - PloS one, 2011 - journals.plos.org
Background Intra-amniotic infection and/or inflammation (IAI) are important causes of
preterm birth and early-onset neonatal sepsis (EONS). A prompt and accurate diagnosis of …

Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ)

V Kolla, P Jenö, S Moes, S Tercanli… - BioMed Research …, 2010 - Wiley Online Library
Currently no specific biomarkers exist for the screening of pregnancies at risk for down
syndrome (DS). Since a quantitative proteomic approach with isobaric labelling (iTRAQ) has …

A methodological and functional proteomic approach of human follicular fluid en route for oocyte quality evaluation

L Bianchi, A Gagliardi, G Campanella, C Landi… - Journal of …, 2013 - Elsevier
Human follicular fluid (HFF) has been proven to contain biologically active molecules and
proteins that may affect follicle growth and oocyte fertilization. Based on this concept, HFF …