In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the …

The positron emission tomography (PET) molecular imaging technique has gained its
universal value as a remarkable tool for medical diagnosis and biomedical research …

Sepsis‐associated encephalopathy (SAE) represents diverse cerebral dysfunctions in
response to pathogen‐induced systemic inflammation. Peripheral exposure to …

Purpose Type 2 diabetes mellitus (T2DM) is associated with a greater risk of Alzheimer's
disease. Synaptic impairment and protein aggregates have been reported in the brains of …

Synapses are implicated in many neuropsychiatric illnesses. Here, we provide an overview
of in vivo techniques to index synaptic markers in patients. Several positron emission …

Chronic innate immune activation is a key hallmark of many neurological diseases and is
known to result in the upregulation of GPR84 in myeloid cells (macrophages, microglia, and …

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a CAG trinucleotide expansion in the huntingtin (HTT) gene that encodes the pathologic …

The positron emission tomography (PET) radioligand [11 C] UCB-J binds to synaptic vesicle
protein 2A (SV2A) and is used to investigate synaptic density in the living brain. Clinical …

The number of functionally active synapses provides a measure of neural integrity, with
reductions observed in neurodegenerative disorders.[11C] UCB-J binds to synaptic vesicle …

The development of novel radiotracers for Positron Emission Tomography (PET) imaging
agents targeting the synaptic vesicle glycoprotein 2 A (SV2A), an integral glycoprotein …