Genetics meets proteomics: perspectives for large population-based studies
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …
complex processes influencing human biology. Proteins represent intermediate phenotypes …
Germline genetic variation and predicting immune checkpoint inhibitor induced toxicity
IS Chin, A Khan, A Olsson-Brown, S Papa… - NPJ Genomic …, 2022 - nature.com
Immune checkpoint inhibitor (ICI) therapy has revolutionised the treatment of various cancer
types. ICIs reinstate T-cell function to elicit an anti-cancer immune response. The resulting …
types. ICIs reinstate T-cell function to elicit an anti-cancer immune response. The resulting …
Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability
Abstract N 6-methyladenosine (m6A) plays important roles in regulating messenger RNA
processing. Despite rapid progress in this field, little is known about the genetic …
processing. Despite rapid progress in this field, little is known about the genetic …
Quality control and removal of technical variation of NMR metabolic biomarker data in~ 120,000 UK Biobank participants
Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy in
approximately 121,000 UK Biobank participants has recently been released as a community …
approximately 121,000 UK Biobank participants has recently been released as a community …
A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer
D Ray, N Chatterjee - PLoS genetics, 2020 - journals.plos.org
There is increasing evidence that pleiotropy, the association of multiple traits with the same
genetic variants/loci, is a very common phenomenon. Cross-phenotype association tests are …
genetic variants/loci, is a very common phenomenon. Cross-phenotype association tests are …
Design control and management of intelligent and autonomous nanorobots with artificial intelligence for Prevention and monitoring of blood related diseases
The effective management of human bloodstream remains to be the prime focus for the
clinicians over years and it impose greater challenges when it comes to real-time solution. In …
clinicians over years and it impose greater challenges when it comes to real-time solution. In …
The genetic basis of autoimmunity seen through the lens of T cell functional traits
KA Lagattuta, HL Park, L Rumker, K Ishigaki… - Nature …, 2024 - nature.com
Autoimmune disease heritability is enriched in T cell-specific regulatory regions of the
genome. Modern-day T cell datasets now enable association studies between single …
genome. Modern-day T cell datasets now enable association studies between single …
[HTML][HTML] The CONSTANCES cohort Biobank: an open tool for research in epidemiology and prevention of diseases
J Henny, R Nadif - Frontiers in Public Health, 2020 - frontiersin.org
“General-purpose cohorts” in epidemiology and public health are designed to cover a broad
scope of determinants and outcomes, in order to answer several research questions …
scope of determinants and outcomes, in order to answer several research questions …
Transcriptional profile of platelets and iPSC-derived megakaryocytes from whole-genome and RNA sequencing
Genome-wide association studies have identified common variants associated with platelet-
related phenotypes, but because these variants are largely intronic or intergenic, their link to …
related phenotypes, but because these variants are largely intronic or intergenic, their link to …
The metabolic fingerprint of COVID-19 severity
Abstract Corona virus disease 2019 (COVID-19) has been associated with a wide range of
divergent pathologies, and risk of severe disease is reported to be increased by a similarly …
divergent pathologies, and risk of severe disease is reported to be increased by a similarly …