Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

Transcription initiation is a major regulatory step in eukaryotic gene expression. Co-
activators establish transcriptionally competent promoter architectures and chromatin …

Interactions between bacteria and fungi have great environmental, medical, and agricultural
importance, but the molecular mechanisms are largely unknown. Here, we study the …

Prior studies suggested that SAGA and TFIID are alternative factors that promote RNA
polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA …

Previous studies suggested that expression of most yeast mRNAs is dominated by either
transcription factor TFIID or SAGA. We re-examined the role of TFIID by rapid depletion of S …

Abstract SAGA (Spt–Ada–Gcn5–acetyltransferase) is a 19-subunit complex that stimulates
transcription via two chromatin-modifying enzymatic modules and by delivering the TATA …

Deletions within genes coding for subunits of the transcription coactivator SAGA caused
strong genome-wide defects in transcription and SAGA-mediated chromatin modifications. In …

The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification,
DNA damage repair and signaling. While structures of yeast SAGA (ySAGA) have been …

There are many large protein complexes involved in transcription in a chromatin context.
However, recent studies on the SAGA coactivator complex are generating new paradigms …

Poaceae plants can locally accumulate iron to suppress pathogen infection. It remains
unknown how pathogens overcome host-derived iron stress during their successful …