Advancements in the synthesis of fused tetracyclic quinoline derivatives

RA Mekheimer, MA Al-Sheikh, HY Medrasi… - RSC advances, 2020 - pubs.rsc.org
Fused tetracyclic systems containing a quinoline nucleus represent an important class of
heterocyclic bioactive natural products and pharmaceuticals because of their significant and …

TBHP Promoted Cross‐Dehydrogenative coupling (CDC) Reaction: Metal/Additive‐Free Synthesis of Chromone‐Fused Quinolines

JB Singh, K Mishra, T Gupta, R M. Singh - ChemistrySelect, 2017 - Wiley Online Library
A metal/additive‐free, TBHP‐promoted synthesis of 12H‐Chromeno [2, 3‐b] quinolin‐12‐
ones from 2‐phenoloxyquinolinyl‐3‐carboxaldehydes has been described via cross …

Metal free TBHP-promoted intramolecular carbonylation of arenes via radical cross-dehydrogenative coupling: synthesis of indenoquinolinones, 4-azafluorenones …

K Mishra, AK Pandey, JB Singh… - Organic & Biomolecular …, 2016 - pubs.rsc.org
A metal-free, TBHP-promoted economical route is developed via the sp2 C–H bond
functionalization strategy for the synthesis of indenoquinolinones, 4-azafluorenones and …

Pd catalyzed facile synthesis of cyclopenta [b] quinolin-1-one via sequential Sonogashira coupling and annulation. An unusual mode of ring closure, using sulphur as …

RM Singh, R Kumar, KC Bharadwaj… - Organic Chemistry …, 2016 - pubs.rsc.org
Pd mediated one pot sequential Sonogashira coupling followed by annulation using o-
alkynyl aldehyde is reported. Contrary to the established modes of ring closures, an unusual …

TBAB-catalyzed cascade reactions: facile synthesis of 1-trifluoromethyl-3-alkylidene-1, 3-dihydrofuro [3, 4-b] quinolines via 5-exo-dig cyclization of o …

K Mishra, JB Singh, T Gupta, RM Singh - Organic Chemistry Frontiers, 2017 - pubs.rsc.org
A convenient method for the facile synthesis of 1-trifluoromethyl-3-alkylidene-1, 3-
dihydrofuro [3, 4-b] quinolines was developed from the TBAB-catalyzed nucleophilic …

Facile synthesis of functionalized 1H-pyrrolo [2, 3-b] quinolines via Ugi four-component reaction followed by Cu-catalyzed aryl-amide, C–N bond coupling

M Asthana, R Kumar, T Gupta, RM Singh - Tetrahedron Letters, 2015 - Elsevier
A simple one-pot two-step reaction comprising an Ugi four-component reaction (Ugi-4CR)
and copper-catalyzed intramolecular amide-aryl cyclization of heteroaryl chloride with amide …

FeCl3· 6H2O-catalyzed facile and efficient synthesis of pyrano [4, 3-b] quinolines and isochromenes

M Asthana, JB Singh, RM Singh - Tetrahedron Letters, 2016 - Elsevier
Abstract An inexpensive 1 mol% FeCl 3· 6H 2 O reagent has been developed for the
synthesis of 1, 3-disubstituted 1H-pyrano [4, 3-b] quinolines from o …

Ligand-free palladium-catalyzed facile construction of tetra cyclic dibenzo [b, h][1, 6] naphthyridine derivatives: domino sequence of intramolecular C–H bond arylation …

JB Singh, KC Bharadwaj, T Gupta, RM Singh - RSC advances, 2016 - pubs.rsc.org
A ligand-free Pd-catalyzed approach has been developed for the synthesis of dibenzo-fused
naphthyridines. The reaction involves a one-pot domino sequence of reactions involving C …

Temperature dependent selective synthesis of linear 2-bromo and 2-alkoxyfuro [2, 3-b] quinolines: reaction of 3-(2, 2-dibromovinyl-) quinolin-2 (1H)-ones with …

D Nandini, M Asthana, K Mishra, RP Singh… - Tetrahedron Letters, 2014 - Elsevier
Base promoted and temperature dependent reactions of 3-(2, 2-dibromovinyl) quinolin-2
(1H)-ones have been described. At 50° C, the cyclization reactions afforded 2-bromofuro [2 …

TBHP-promoted oxidative cyclization of o-alkynylquinoline aldehydes: Metal/additive-free domino synthesis of pyrano [4, 3-b] quinolin-1-ones

JB Singh, K Mishra, T Gupta, RM Singh - Tetrahedron Letters, 2018 - Elsevier
TBHP-promoted domino synthesis of pyrano [4, 3-b] quinolin-1-ones is described from o-
alkynylquinoline aldehydes. The radical reaction proceeded without metal and additive via …