Endocannabinoids work as retrograde messengers and contribute to short-term and long-
term modulation of synaptic transmission via presynaptic cannabinoid receptors. It is …

A systematic study of the structure− activity relationships of 2b (OL-135), a potent inhibitor of
fatty acid amide hydrolase (FAAH), is detailed targeting the C2 acyl side chain. A series of …

For more than a decade, a considerable amount of research has examined the effects of
rimonabant (SR 141716) and other CB1 receptor antagonists in both in vivo and in vitro …

Depression is a complex psychiatric disorder, and its etiology and pathophysiology are not
completely understood. Depression involves changes in many biogenic amine …

A study of the structure− activity relationships (SAR) of 2f (OL-135), a potent inhibitor of fatty
acid amide hydrolase (FAAH), is detailed, targeting the 5-position of the oxazole …

The endocannabinoid system, through the cannabinoid type 1 (CB1) and 2 (CB2) receptors
modulates many physiological functions, including different aspects of memory-related …

Recent studies show contradictory results regarding the contribution of endocannabinoids in
fear memory formation and long-term synaptic plasticity. In this study, we investigated the …

Premutation carriers have a 55–200 CGG expansion in the fragile X mental retardation 1
(FMR1) gene. Currently, 1.5 million individuals are affected in the United States, and carriers …

This study investigated the role of two fatty acid ethanolamides, the endogenous
cannabinoid anandamide and its structural analog oleoylethanolamide in sleep deprivation …

The endocannabinoid system is involved in the fine-tuning of local synaptic plasticity in the
hippocampus during the initial steps of memory formation/transformation. In spite of …