In addition to inducing lethal DNA damage in tumor and stromal cells, radiation can alter the
interactions of tumor cells with their microenvironment. Recent technological advances in …

New radiation modalities have made it possible to prolong the survival of individuals with
malignant brain tumors, but symptomatic radiation necrosis becomes a serious problem that …

Background Treatment options for unresectable new and recurrent glioblastoma remain
limited. Laser ablation has demonstrated safety as a surgical approach to treating primary …

Purpose Radiation necrosis (RN) represents a serious post-radiotherapy complication in
patients with brain metastases. Bevacizumab and laser interstitial thermal therapy (LITT) are …

Background Radiotherapy is the mainstay of brain metastasis (BM) management. Radiation
necrosis (RN) is a serious complication of radiotherapy. Bevacizumab (BV), an anti-vascular …

Background Brain radionecrosis (tissue death caused by radiation) can occur following high‐
dose radiotherapy to brain tissue and can have a significant impact on a person's quality of …

Cancer therapy-induced adverse effects on the brain are a major challenge in neuro-
oncology. Brain tissue necrosis (treatment necrosis [TN]) as a consequence of brain directed …

BACKGROUND Radiosurgical failure following stereotactic radiosurgery for brain
metastases can be attributed to tumor regrowth or radiation necrosis. MRI-guided laser …

Purpose: To quantify the effectiveness of anti-VEGF antibodies (bevacizumab and B20-4.1.
1) as mitigators of radiation-induced, central nervous system (brain) necrosis in a mouse …

Background Prior retrospective and prospective studies suggest improved survival with the
use of stereotactic radiosurgery (SRS) and bevacizumab in the treatment of limited-volume …