Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

Peptide therapy has started since 1920s with the advent of insulin application, and now it
has emerged as a new approach in treatment of diseases including cancer. Using anti …

The physical properties of lipid bilayers are sensitive to the specific type and composition of
the lipids that make up the many different types of cell membranes. Studying model bilayers …

Cell membrane structure is proposed as a lipid matrix with embedded proteins, and thus,
their emerging mechanical and electrostatic properties are commanded by lipid behavior …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Biophysical studies have a very high impact on the understanding of internalization,
molecular mechanisms, interactions, and localization of CPPs and CPP/cargo conjugates in …

Peptides, biopolymeric compounds connected by peptide bonds, have garnered significant
attention in recent years as their potential wide applications in fields such as drug delivery …

With the ability to transport cargo molecules across cell membranes with low toxicity, cell-
penetrating peptides (CPPs) have become promising candidates for next generation peptide …

Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules.
The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based …

In this introductory chapter, we first define cell-penetrating peptides (CPPs), give short
overview of CPP history and discuss several aspects of CPP classification. Next section is …