Protein glycosylation is a posttranslational modification that affects more than half of all
known proteins. Glycans covalently bound to biomolecules modulate their functions by both …

Human osteopontin (OPN) is a glycosylated phosphoprotein which is expressed in a variety
of tissues in the body. In recent years, accumulating evidence has indicated that the aberrant …

Glioblastoma multiforme (GBM) is the most common and lethal form of intracranial tumor. We
have established a lentivirus-induced mouse model of malignant gliomas, which faithfully …

Interconversion of transformed non-stem cells to cancer stem cells, termed cancer cell
plasticity, contributes to intra-tumor heterogeneity and its molecular mechanisms are …

Glioblastoma is considered one of the most aggressive malignancies in adult and pediatric
patients. Despite decades of research no curative treatment is available and it thus remains …

Epigenetic mechanisms which play an essential role in normal developmental processes,
such as self-renewal and fate specification of neural stem cells (NSC) are also responsible …

The poor prognosis of glioblastoma multiforme (GBM) is primarily due to highly invasive
glioma stem-like cells (GSCs) in tumors. Upon GBM recurrence, GSCs with highly invasive …

The glycoprotein osteopontin is highly upregulated in central nervous system (CNS)
disorders such as ischemic stroke. Osteopontin regulates cell growth, cell adhesion …

Simple Summary 5-ALA Fluorescence Guided Surgery aims at extending the boundaries of
glioblastoma (GBM) resection. It is based on the use of a fluorescent dye, 5-aminolevulinic …

Glioblastoma multiforme (GBM), designated as World Health Organization (WHO) grade IV
astrocytoma, is a lethal and therapy-resistant brain cancer comprised of several tumor cell …