Challenges of applying multicellular tumor spheroids in preclinical phase
SJ Han, S Kwon, KS Kim - Cancer cell international, 2021 - Springer
Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …
becoming an essential tool in cancer research as it expresses an intermediate complexity …
Engineering multi‐cellular spheroids for tissue engineering and regenerative medicine
Multi‐cellular spheroids are formed as a 3D structure with dense cell–cell/cell–extracellular
matrix interactions, and thus, have been widely utilized as implantable therapeutics and …
matrix interactions, and thus, have been widely utilized as implantable therapeutics and …
Spheroid engineering in microfluidic devices
Two-dimensional (2D) cell culture techniques are commonly employed to investigate
biophysical and biochemical cellular responses. However, these culture methods, having …
biophysical and biochemical cellular responses. However, these culture methods, having …
A 3D printed hanging drop dripper for tumor spheroids analysis without recovery
L Zhao, J Xiu, Y Liu, T Zhang, W Pan, X Zheng… - Scientific reports, 2019 - nature.com
Compared with traditional monolayer cell culture, the three-dimensional tumor spheroid has
emerged as an essential in vitro model for cancer research due to the recapitulation of the …
emerged as an essential in vitro model for cancer research due to the recapitulation of the …
In vitro glioblastoma models: A journey into the third dimension
M Paolillo, S Comincini, S Schinelli - Cancers, 2021 - mdpi.com
Simple Summary In this review, the thorny issue of glioblastoma models is addressed, with a
focus on 3D in vitro models. In the first part of the manuscript, glioblastoma features and …
focus on 3D in vitro models. In the first part of the manuscript, glioblastoma features and …
Primary human pancreatic cancer cells cultivation in microfluidic hydrogel microcapsules for drug evaluation
Chemotherapy is an essential postoperative treatment for pancreatic cancer, while due to
the lack of effective drug evaluation platforms, the therapeutic outcomes are hampered by …
the lack of effective drug evaluation platforms, the therapeutic outcomes are hampered by …
A pH-sensitive nanocarrier based on BSA-stabilized graphene-chitosan nanocomposite for sustained and prolonged release of anticancer agents
S Gooneh-Farahani, SM Naghib, MR Naimi-Jamal… - Scientific Reports, 2021 - nature.com
Smart nanomaterials with stimuli-responsive behavior are considered as promising platform
for various drug delivery applications. Regarding their specific conditions, such as acidic pH …
for various drug delivery applications. Regarding their specific conditions, such as acidic pH …
Recent advances in microfluidic technologies for organ-on-a-chip
C Tian, Q Tu, W Liu, J Wang - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
Abstract Organ-on-a-chip (OOC) systems were developed by combining microfluidic
technologies and tissue engineering to mimic physiological conditions in the body. OOC …
technologies and tissue engineering to mimic physiological conditions in the body. OOC …
A combined 3D printing/CNC micro-milling method to fabricate a large-scale microfluidic device with the small size 3D architectures: An application for tumor spheroid …
The fabrication of a large-scale microfluidic mold with 3D microstructures for manufacturing
of the conical microwell chip using a combined projection micro-stereolithography (PµSL) …
of the conical microwell chip using a combined projection micro-stereolithography (PµSL) …
A comprehensive review on scaffold-free bioinks for bioprinting
N Khoshnood, A Zamanian - Bioprinting, 2020 - Elsevier
Abstract 3D bioprinting technology has been an interest in constructing tissue engineering
scaffolds due to its high resolution and repeatability, ability to fabricate complex construct …
scaffolds due to its high resolution and repeatability, ability to fabricate complex construct …