G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …

The α1-adrenergic receptors (ARs) are G-protein coupled receptors that bind the
endogenous catecholamines, norepinephrine, and epinephrine. They play a key role in the …

Cell therapy treatment of myocardial infarction (MI) is mediated, in part, by exosomes
secreted from transplanted cells. Thus, we compared the efficacy of treatment with a mixture …

Background Mitochondrial fusion protein mutations are a cause of inherited neuropathies
such as Charcot–Marie–Tooth disease and dominant optic atrophy. Previously we reported …

Enhanced reactive oxygen species (ROS) at the beginning of reperfusion activated signal
transducer and activator of transcription 3 (STAT3) in intermittent hypobaric hypoxia (IHH) …

Ischemia and reperfusion (I/R) cause a reduction in arterial blood supply to tissues, followed
by the restoration of perfusion and consequent reoxygenation. The reestablishment of blood …

The heart is richly innervated by sympathetic nerves, and both acute and chronic regulation
of cardiac function via sympathetically released catecholamines acting on cardiomyocyte …

Cardiac mitochondria are powerful organelles supplying energy to support the high
adenosine triphosphate (ATP) consumption of the beating heart. The progression of HF (HF) …

Sympathetic nervous system regulation by the α1-adrenergic receptor (AR) subtypes (α1A,
α1B, α1D) is complex, whereby chronic activity can be either detrimental or protective for …

Abstract Aims Heat shock protein 27 (Hsp27) renders cardioprotection from
ischaemia/reperfusion (I/R) injury, but little is known about its role in myofilaments. We …