In the human body, glycogen is a branched polymer of glucose stored mainly in the liver and
the skeletal muscle that supplies glucose to the blood stream during fasting periods and to …

Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …

The mechanics of the cellular microenvironment continuously modulates cell functions such
as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal …

Altered glycolysis is a hallmark of diseases including diabetes and cancer. Despite intensive
study of the contributions of individual glycolytic enzymes, systems-level analyses of flux …

Dysregulated pH is a common characteristic of cancer cells, as they have an increased
intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells …

Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …

In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the
pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen …

Virus-infected cells and cancers share metabolic commonalities that stem from their
insatiable need to replicate while evading the host immune system. These similarities …

Glucose metabolism enzymes and transporters play major role in cancer development and
metastasis. In this study, we discuss glucose metabolism, transporters, receptors, hormones …

EGFR activates phosphatidylinositide 3-kinase (PI3K), but the mechanism underlying this
activation is not completely understood. We demonstrated here that EGFR activation …