This Tutorial is to provide a summary of parameters useful for successful outcomes of
laserspray ionization (LSI) and related methods that employ a laser to ablate a matrix …

In this review we highlight the general change in perception in the field of ambient mass
spectrometry that it is the immediacy of sample preparation that differentiates the ambient …

Together with my group and collaborators, I have been fortunate to have had a key role in
the discovery of new ionization processes that we developed into new flexible, sensitive …

The definition of ambient ionization is updated from “no sample preparation” to sample
preparation proximal and in real time with the ionization and analysis step. We differentiate …

Mechanistic arguments relative to matrix-assisted laser desorption/ionization (MALDI) mass
spectrometry (MS) address observations that predominately singly charged ions are …

The systematic study of the temperature and pressure dependence of matrix-assisted
ionization (MAI) led us to the discovery of the seemingly impossible, initially explained by …

An astonishingly simple new method to produce gas-phase ions of small molecules as well
as proteins from the solid state under cold vacuum conditions is described. This matrix …

Matrix assisted inlet ionization (MAII) is a method in which a matrix: analyte mixture
produces mass spectra nearly identical to electrospray ionization without the application of a …

Desorption electrospray ionization mass spectrometry (DESI‐MS) requires little to no sample
preparation and has been successfully applied to the study of biologically significant …

This is the first report of imaging mass spectrometry (MS) from multiply charged ions at
vacuum. Laserspray ionization (LSI) was recently extended to applications at vacuum …