R-amino acid reductions, allow entry to other classes of compounds that are also useful as
the source of chiral centers, as with R-amino aldehydes, that, in turn, can be used in a …

The chemistry of lithium enolates is used to demonstrate that complex structures held
together by noncovalent bonds (“supramolecules”) may dramatically influence the result of …

There was a time in organic chemistry when the olefination of ketones and aldehydes was
faced with some trepidation. Because of limited synthetic meth-ods, as recently as 30 years …

2-Oxazolines have permeated numerous sub-disciplines in synthetic organic chemistry in
the 100 years since their discovery. This versatile heterocycle has served as protecting …

An overview is given of the recent trends in the synthesis of naturally occurring 8-and 9-
membered lactones. During the past three decades of synthetic studies of medium-sized …

The stereoselective total synthesis of structure 1 assigned to the macrolide natural product
neaumycin B is reported in a 2.3% overall yield on 90 mg scale. The synthesis features a …

1. Introduction Nature has stocked the seas with a seemingly limitless range of diverse and
often highly complex secondary metabolites, which exhibit one or more of a variety of …

Cyclic peptides including cyclic depsipeptides are still a growing research area even in the
21st century. 1 They are mainly produced by marine organisms and terrestrial …

The total synthesis of the marine macrolide bryostatin 2 is described. The synthesis plan
relies on aldol and directed reduction steps in order to construct the anti-1, 3-diol array …

A simple,'one-pot'procedure for the conversion of vicinal diols into epoxides via halohydrin
ester intermediates has been developed. This method tolerates a wide range of functionality …