Nephrotoxicity is one of the most important side effects and therapeutical limitations of
aminoglycoside antibiotics, especially gentamicin. Despite rigorous patient monitoring …

Due to high relative blood flow the kidney is prone to drug-induced damage.
Aminoglycoside type antibiotic gentamicin is one of the leading cause of drug-induced …

The antidiabetic drug metformin can diminish apoptosis induced by oxidative stress in
endothelial cells and prevent vascular dysfunction even in nondiabetic patients. Here we …

Aminoglycoside antibiotics are the most commonly used antibiotics worldwide in the
treatment of Gram-negative bacterial infections. However, aminoglycosides induce …

Apoptosis plays a central role not only in the physiological processes of kidney growth and
remodeling, but also in various human renal diseases and drug-induced nephrotoxicity. We …

Chronic kidney disease of unknown etiology (CKDu) is an emerging global concern
affecting several agricultural communities in the Americas and South Asia. Environmental …

AKI affects approximately 13.3 million people around the world each year, causing CKD
and/or mortality. The mammalian kidney cannot generate new nephrons after postnatal …

Nephrotoxicity is a serious complication that limits the clinical use of gentamicin (GEN).
Parthenolide (PTL) is a sesquiterpene lactone derived from feverfew with various …

Gentamicin accumulates in lysosomes and induces apoptosis in kidney proximal tubules
and renal cell lines. Using LLC-PK1 cells, we have examined the concentration-and time …

The histological substrate of many forms of intrinsic acute kidney injury (AKI) has been
classically attributed to tubular necrosis. However, more recent studies indicate that necrosis …