Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …

In addition to physical barriers, neutrophils are considered a part of the first line of immune
defense. They can be found in the bloodstream, with a lifespan of 6–8 h, and in tissue …

Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors
determining disease progression are unclear. Transcriptional signatures associated with …

Beyond their well-known functions in the acute phases of the immune response, neutrophils
play important roles in the various phases of tumor initiation and progression, through the …

Systemic autoimmune diseases are a group of disorders characterized by a failure in self-
tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these …

Spectacular images of neutrophils ejecting nuclear chromatin and bactericidal proteins, in
response to microbes, were first reported in 2004. As externalized chromatin could entangle …

Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular
and selected cytoplasmic proteins. NETs are released by white blood cells called …

Recent data suggest that NETosis plays a crucial role in the innate immune response and
disturbs the homeostasis of the immune system. NETosis is a form of neutrophil-specific cell …

Neutrophils release decondensed chromatin termed neutrophil extracellular traps (NETs) to
trap and kill pathogens extracellularly. Reactive oxygen species are required to initiate NET …