Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG)

M Ozga, D Nicolet, K Mrózek, AS Yilmaz, J Kohlschmidt… - Leukemia, 2024 - nature.com
Clinical outcome of patients with acute myeloid leukemia (AML) is associated with
demographic and genetic features. Although the associations of acquired genetic alterations …

Advances in molecular characterization of myeloid proliferations associated with Down syndrome

J Li, ML Kalev-Zylinska - Frontiers in genetics, 2022 - frontiersin.org
Myeloid leukemia associated with Down syndrome (ML-DS) has a unique molecular
landscape that differs from other subtypes of acute myeloid leukemia. ML-DS is often …

Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity

M Schwede, K Jahn, J Kuipers, LA Miles, RL Bowman… - Leukemia, 2024 - nature.com
Acute myeloid leukemia (AML) has a poor prognosis and a heterogeneous mutation
landscape. Although common mutations are well-studied, little research has characterized …

Molecular measurable residual disease monitoring and transplant indications in NPM1 mutated acute myeloid leukemia

MR Christopher, MT Nawas, JL Reagan - Bone Marrow Transplantation, 2024 - nature.com
NPM1 mutated acute myeloid leukemia (AML) comprises roughly 30% of all AML cases and
is mainly classified as favorable or intermediate-risk according to the European Leukemia …

Clinical implications of NUP98::NSD1 fusion at diagnosis in adult FLT3‐ITD positive AML

T Miyajima, M Onozawa, S Yoshida… - European Journal of …, 2023 - Wiley Online Library
Objectives The cryptic fusion oncogene NUP98:: NSD1 is known to be associated with FLT3‐
ITD mutation in acute myeloid leukemia (AML), and an independent poor prognostic factor in …

Wilms' tumor gene 1 in hematological malignancies: friend or foe?

J Wu, H Yan, C Xiang - Hematology, 2023 - Taylor & Francis
ABSTRACT Wilms' tumor gene 1 (WT1) is a transcription and post-translational factor that
has a crucial role in the biological and pathological processes of several human …

Genetic features and outcomes of allogeneic transplantation in patients with WT1-mutated myeloid neoplasms

A Baranwal, R Basmaci, R He, D Viswanatha… - Blood …, 2024 - ashpublications.org
The Wilms tumor 1 (WT1) gene, located at locus 11p13, is a tumor suppressor gene that
encodes a zinc-finger transcription factor. 1, 2 The presence of WT1 gene mutation (mWT1) …

NPM1‐mutated myeloid neoplasms are a unique entity not defined by bone marrow blast percentage

G Gener‐Ricos, A Bataller, JJ Rodriguez‐Sevilla… - Cancer, 2024 - Wiley Online Library
Abstract Introduction NPM1‐mutated (NPM1mut) myeloid neoplasms (MNs) with< 20% bone
marrow (BM) blasts (NPM1mut MNs< 20) are uncommon, and their classification remains …

[Retracted] Research Progress of B‐Cell Lymphoma/Leukemia‐2 Inhibitor Combined with Azacytidine in the Targeted Therapy of Acute Myeloid Leukemia

Y Wang, D Huang, L Liu, A Wang… - … Methods in Medicine, 2022 - Wiley Online Library
Objective. To investigate the efficacy and safety of azacytidine and B‐cell
lymphoma/leukemia‐2 inhibitors in the treatment of patients with acute myeloid leukemia …

[PDF][PDF] Modelling the Risk Factors of Breast Cancer in Vitro

IE Bray - 2023 - research-information.bris.ac.uk
Breast cancer accounts for around 25% of all newly-diagnosed cancers, and is one of the
leading causes of cancer-related death in women due to a high rate of relapse and …