Molecular insights into the selective binding mechanism targeting parallel human telomeric G-quadruplex
Stabilizing human telomere DNA G-quadruplex (G4) proves a promising anti-cancer
strategy. Though plenty of G4 stabilizing molecules have been reported, little is known about …
strategy. Though plenty of G4 stabilizing molecules have been reported, little is known about …
Engineered histidine-enriched facial Lipopeptides for enhanced intracellular delivery of functional siRNA to triple negative breast Cancer cells
Cytosolic delivery of functional siRNA remains the major challenge to develop siRNA-based
therapeutics. Designing clinically safe and effective siRNA transporter to deliver functional …
therapeutics. Designing clinically safe and effective siRNA transporter to deliver functional …
Rnabpdb: Molecular modeling of rna structure—From base pair analysis in crystals to structure prediction
The stable three-dimensional structure of RNA is known to play several important
biochemical roles, from post-transcriptional gene regulation to enzymatic action. These …
biochemical roles, from post-transcriptional gene regulation to enzymatic action. These …
In search of an efficient Photoswitch for functional RNA: design principles from a microscopic analysis of Azobenzene-linker-RNA dynamics with different linkers
The design of optimal photoswitches to regulate nucleic acid functionality is a considerable
challenge. Azobenzene switches that are covalently bound to the nucleic acid backbone are …
challenge. Azobenzene switches that are covalently bound to the nucleic acid backbone are …
Structural Switch from Hairpin to Duplex/Antiparallel G-Quadruplex at Single-Nucleotide Polymorphism (SNP) Site of Human Apolipoprotein E (APOE) Gene Coding …
A gradual dementia, which leads to the loss of memory and intellectual abilities, is the main
characteristics of Alzheimer's disease. Amyloid-β (Aβ) plaques are the main components …
characteristics of Alzheimer's disease. Amyloid-β (Aβ) plaques are the main components …
RNABP COGEST: a resource for investigating functional RNAs
Structural bioinformatics of RNA has evolved mainly in response to the rapidly accumulating
evidence that non-(protein)-coding RNAs (ncRNAs) play critical roles in gene regulation and …
evidence that non-(protein)-coding RNAs (ncRNAs) play critical roles in gene regulation and …
Introducing structure–energy concepts of RNA at the undergraduate level: nearest neighbor thermodynamics and NMR spectroscopy of a GAGA tetraloop
Two-dimensional nuclear magnetic resonance (2D NMR) techniques are regularly used for
the determination of RNA structures. In an effort to introduce advanced level students who …
the determination of RNA structures. In an effort to introduce advanced level students who …
Probing the microscopic structure and flexibility of oxidized DNA by molecular simulations
The oxidative damage of DNA is a compelling issue in molecular biophysics as it plays a
vital role in the epigenetic control of gene expression and is believed to be associated with …
vital role in the epigenetic control of gene expression and is believed to be associated with …
Structural switching/polymorphism by sequential base substitution at quasi-palindromic SNP site (G→ A) in LCR of human β-globin gene cluster
The human β-globin gene Locus Control Region (LCR), a dominant regulator of globin gene
expression contains five tissue-specific DNase I-hypersensitive sites (HSs). A single …
expression contains five tissue-specific DNase I-hypersensitive sites (HSs). A single …
Sequence specificity in DNA–drug intercalation: MD simulation and density functional theory approaches
L Maganti, D Bhattacharyya - Journal of computer-aided molecular design, 2020 - Springer
DNA is an essential target for the treatment of various pathologies, especially cancer. Hence
targeting DNA double helix for alteration of its function has been attempted by several ways …
targeting DNA double helix for alteration of its function has been attempted by several ways …