Electrophilic products of lipid peroxidation are important contributors to the progression of
several pathological states. The prototypical α, β–unsaturated aldehyde, 4-hydroxynonenal …

Many biopolymers, including polysaccharides, must be translocated across at least one
membrane to reach their site of biological function. Cellulose is a linear glucose polymer …

Abstract Glutathione-S-transferase (GST) inhibition is a strategy to overcome drug
resistance. Several isoforms of human GSTs are present and they are expressed in almost …

Protein structures are classically described as composed of two regular states, the α-helices
and the β-strands and one non-regular and variable state, the coil. Nonetheless, this simple …

Human glutathione transferase A1-1 is a well studied enzyme, but despite a wealth of
structural and biochemical data a number of aspects of its catalytic function are still poorly …

The identification of molecular mechanisms underlying enzyme cold adaptation is a hot-
topic both for fundamental research and industrial applications. In the present contribution …

Recent reports which show that several chemokines can act as direct microbicidal agents
have drawn renewed attention to these chemotactic signalling proteins. Here we present a …

Enzymological paradigms have shifted recently to acknowledge the biological importance of
catalytic promiscuity. However, catalytic promiscuity is a poorly understood property, and no …

The specificity of human glutathione transferase (GST) A1-1 is drastically altered to favor
alkenal substrates in the GIMFhelix mutant designed to mimic first-sphere interactions …

Protein structures are often represented as seen in crystals as (i) rigid macromolecules (ii)
with helices, sheets and coils. However, both definitions are partial because (i) proteins are …