[HTML][HTML] Diabetes-induced changes in cardiac voltage-gated ion channels
Diabetes mellitus affects the heart through various mechanisms such as microvascular
defects, metabolic abnormalities, autonomic dysfunction and incompatible immune …
defects, metabolic abnormalities, autonomic dysfunction and incompatible immune …
Calcium signaling in diabetic cardiomyocytes
Diabetes mellitus is one of the most common medical conditions. It is associated to medical
complications in numerous organs and tissues, of which the heart is one of the most …
complications in numerous organs and tissues, of which the heart is one of the most …
[HTML][HTML] Increased oxidative stress and mitochondrial dysfunction in zucker diabetic rat liver and brain
H Raza, A John, FC Howarth - Cellular Physiology and Biochemistry, 2015 - karger.com
Background/Aims: The Zucker diabetic fatty (ZDF, FA/FA) rat is a genetic model of type 2
diabetes, characterized by insulin resistance with progressive metabolic syndrome. We have …
diabetes, characterized by insulin resistance with progressive metabolic syndrome. We have …
Structural and electrical remodeling of the sinoatrial node in diabetes: new dimensions and perspectives
The sinoatrial node (SAN) is composed of highly specialized cells that mandate the
spontaneous beating of the heart through self-generation of an action potential (AP). Despite …
spontaneous beating of the heart through self-generation of an action potential (AP). Despite …
Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease and left ventricular diastolic dysfunction
Chronic kidney disease (CKD) is an independent risk factor for the development of heart
failure, but the underlying mechanisms remain unknown. Using a novel translational swine …
failure, but the underlying mechanisms remain unknown. Using a novel translational swine …
Alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly Zucker diabetic fatty rat heart
H Raza, A John, FC Howarth - International journal of molecular sciences, 2012 - mdpi.com
The Zucker diabetic fatty (ZDF) rat is a genetic model in which the homozygous (FA/FA) male
animals develop obesity and type 2 diabetes. Morbidity and mortality from cardiovascular …
animals develop obesity and type 2 diabetes. Morbidity and mortality from cardiovascular …
Cardiac ion channel regulation in obesity and the metabolic syndrome: relevance to long QT syndrome and atrial fibrillation
AS Aromolaran, M Boutjdir - Frontiers in physiology, 2017 - frontiersin.org
Obesity and its associated metabolic dysregulation leading to metabolic syndrome is an
epidemic that poses a significant public health problem. More than one-third of the world …
epidemic that poses a significant public health problem. More than one-third of the world …
High-density lipoprotein is located alongside insulin in the islets of Langerhans of normal and rodent models of diabetes
S Mohsin, H Elabadlah, MK Alotaiba, S AlAmry… - Nutrients, 2024 - mdpi.com
Recent studies have implicated pre-beta and beta lipoproteins (VLDL and LDL) in the
etiopathogenesis of complications of diabetes mellitus (DM). In contrast, alpha lipoprotein …
etiopathogenesis of complications of diabetes mellitus (DM). In contrast, alpha lipoprotein …
Enhanced oxidative stress sensitizes the mitochondrial permeability transition pore to opening in heart from Zucker Fa/fa rats with type 2 diabetes
A Riojas-Hernández, J Bernal-Ramírez… - Life sciences, 2015 - Elsevier
Aims Obesity and diabetes mellitus type 2 (DM2) frequently coexist and increase the
propensity of cardiovascular dysfunction by numerous mechanisms. Chief among them are …
propensity of cardiovascular dysfunction by numerous mechanisms. Chief among them are …
Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose
Hearts from type 2 diabetic (T2DM) subjects are chronically subjected to hyperglycemia and
hyperlipidemia, both thought to contribute to oxidizing conditions and contractile dysfunction …
hyperlipidemia, both thought to contribute to oxidizing conditions and contractile dysfunction …