Recent advances in c-Met-based dual inhibitors in the treatment of cancers
F Jin, Y Lin, W Yuan, S Wu, M Yang, S Ding… - European Journal of …, 2024 - Elsevier
The cellular-mesenchymal epithelial transition factor (c-Met) is a receptor tyrosine kinase
(RTK) located on the 7q31 locus encoding the Met proto-oncogene and plays a critical role …
(RTK) located on the 7q31 locus encoding the Met proto-oncogene and plays a critical role …
Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular …
In the current medical era, developing new PIM-1 inhibitors stands as a significant approach
to cancer management due to the pivotal role of PIM-1 kinase in promoting cell survival …
to cancer management due to the pivotal role of PIM-1 kinase in promoting cell survival …
Fragment-based design and synthesis of coumarin-based thiazoles as dual c-MET/STAT-3 inhibitors for potential antitumor agents
Abstract c-MET and STAT-3 are significant targets for cancer treatments. Here, we describe
a class of very effective dual STAT-3 and c-MET inhibitors with coumarin-based thiazoles …
a class of very effective dual STAT-3 and c-MET inhibitors with coumarin-based thiazoles …
Current scenario of pyrazole hybrids with anti‐breast cancer therapeutic applications
M Ma - Archiv der Pharmazie, 2024 - Wiley Online Library
Breast cancer stands as the leading cause of cancer‐related deaths among women globally,
but current therapy is restricted to the serious adverse effects and multidrug resistance …
but current therapy is restricted to the serious adverse effects and multidrug resistance …
Discovery of new 1, 3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in …
Interest has been generated in VEGFR-2 and c-MET as potential receptors for the treatment
of different malignancies. Using aryl pyridine derivatives with 1, 3-diphenylurea attached, a …
of different malignancies. Using aryl pyridine derivatives with 1, 3-diphenylurea attached, a …
Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic …
Schiff bases tethered with sulfonamide functionality (6a-l) are reported as potential
anticancer agents and apoptotic inducers. The anti-proliferative activities of the tested Schiff …
anticancer agents and apoptotic inducers. The anti-proliferative activities of the tested Schiff …
Synthesis of novel pyridine and pyrazolyl pyridine conjugates with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors and caspase activators
A novel series of nicotinonitrile and pyrazolyl nicotinonitrile were synthesized, and their PIM-
1 kinase inhibitors and caspase activators were investigated. New Manich bases 6–8 were …
1 kinase inhibitors and caspase activators were investigated. New Manich bases 6–8 were …
Cancer research in the United Arab Emirates from birth to present: A bibliometric analysis
Background Accumulating evidence indicates that the incidence of cancer is increasing in
the United Arab Emirates (UAE). This analysis aimed to determine the current cancer …
the United Arab Emirates (UAE). This analysis aimed to determine the current cancer …