[HTML][HTML] Protective mechanisms and current clinical evidence of hypothermic oxygenated machine perfusion (HOPE) in preventing post-transplant cholangiopathy

A Schlegel, RJ Porte, P Dutkowski - Journal of Hepatology, 2022 - Elsevier
The development of cholangiopathies after liver transplantation impacts on the quality and
duration of graft and patient survival, contributing to higher costs as numerous interventions …

Viability assessment in liver transplantation—what is the impact of dynamic organ preservation?

R Panconesi, M Flores Carvalho, M Mueller… - Biomedicines, 2021 - mdpi.com
Based on the continuous increase of donor risk, with a majority of organs classified as
marginal, quality assessment and prediction of liver function is of utmost importance. This is …

Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death

R van Rijn, N Karimian, APM Matton… - Journal of British …, 2017 - academic.oup.com
Background Experimental studies have suggested that end-ischaemic dual hypothermic
oxygenated machine perfusion (DHOPE) may restore hepatocellular energy status and …

A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation

A Schlegel, M van Reeven, K Croome, A Parente… - Journal of …, 2022 - Elsevier
Background & Aims The concept of benchmarking is established in the field of transplant
surgery; however, benchmark values for donation after circulatory death (DCD) liver …

The UK DCD Risk Score: a new proposal to define futility in donation-after-circulatory-death liver transplantation

A Schlegel, M Kalisvaart, I Scalera, RW Laing… - Journal of …, 2018 - Elsevier
Background & Aims Primary non-function and ischaemic cholangiopathy are the most feared
complications following donation-after-circulatory-death (DCD) liver transplantation. The aim …

Development and validation of a comprehensive model to estimate early allograft failure among patients requiring early liver retransplant

AW Avolio, A Franco, A Schlegel, Q Lai, S Meli… - JAMA …, 2020 - jamanetwork.com
Importance Expansion of donor acceptance criteria for liver transplant increased the risk for
early allograft failure (EAF), and although EAF prediction is pivotal to optimize transplant …

Favorable outcomes of liver transplantation from controlled circulatory death donors using normothermic regional perfusion compared to brain death donors

E Savier, C Lim, M Rayar, F Orlando, K Boudjema… - …, 2020 - journals.lww.com
Background. Liver transplantation (LT) from controlled donation after circulatory death
(cDCD) was initiated in France in 2015 under a protocol based on the use of normothermic …

[PDF][PDF] Development of clinical criteria for functional assessment to predict primary nonfunction of high‐risk livers using normothermic machine perfusion

H Mergental, BTF Stephenson, RW Laing… - Liver …, 2018 - Wiley Online Library
Increased use of high‐risk allografts is critical to meet the demand for liver transplantation.
We aimed to identify criteria predicting viability of organs, currently declined for clinical …

Donor warm ischemia time in DCD liver transplantation—working group report from the ILTS DCD, liver preservation, and machine perfusion consensus conference

M Kalisvaart, KP Croome… - …, 2021 - journals.lww.com
Donation after circulatory death (DCD) grafts are commonly used in liver transplantation.
Attributable to the additional ischemic event during the donor warm ischemia time (DWIT) …

Evolving trends in machine perfusion for liver transplantation

P Dutkowski, JV Guarrera, J De Jonge… - …, 2019 - gastrojournal.org
The imbalance between grafts available for transplantation and demands has moved the
focus of many investigators on the search for novel strategies to rescue organs, previously …