Babesiosis is a disease with a world-wide distribution affecting many species of mammals
principally cattle and man. The major impact occurs in the cattle industry where bovine …

Despite being one of the most prevalent tropical diseases, for many years malaria was not a
commercial priority for the pharmaceutical industry. However, in response to the emergence …

The fatty acid synthesis type II pathway has received considerable interest as a candidate
therapeutic target in Plasmodium falciparum asexual blood-stage infections. This apicoplast …

The modern age of drug discovery, which had been slowly gathering momentum during the
early part of the twentieth century, exploded into life in the 1940s with the isolation of …

Lipid metabolism is of crucial importance for pathogens. Lipids serve as cellular building
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …

Overcoming resistance: Isoniazid (INH) is a frontline antitubercular drug that inhibits the
enoyl acyl carrier protein reductase InhA. Novel inhibitors of InhA that are not cross‐resistant …

The malaria parasite Plasmodium possesses a relict, non-photosynthetic plastid known as
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …

Abstract Development of new anti-bacterial agents acting upon underexploited targets and
thus evading known mechanisms of resistance is the need of the hour. The highly conserved …

The control and eventual eradication of human malaria is considered one of the most
important global public health goals of the 21st Century. Malaria, caused by intraerythrocytic …

Abstract A series of 2-(2-hydrazinyl) thiazole derivatives with a wide range of substitutions at
2-, 4-and 5-positions were synthesized, characterized and evaluated their inhibitory …