Sex differences in renal transporters: assessment and functional consequences

AA McDonough, AN Harris, L Xiong… - nature reviews …, 2024 - nature.com
Mammalian kidneys are specialized to maintain fluid and electrolyte homeostasis. The
epithelial transport processes along the renal tubule that match output to input have long …

Etiopathogenic factors of urolithiasis

CA Wagner - Archivos espanoles de urologia, 2021 - zora.uzh.ch
INTRODUCTION Kidney stone disease affects 1 in 10 persons at least once per life-time
worldwide, in 2% the disease is recurrent. For the individual stone disease can be painful …

Sex differences in solute transport along the nephrons: effects of Na+ transport inhibition

R Hu, AA McDonough… - American Journal of …, 2020 - journals.physiology.org
Each day,~ 1.7 kg of NaCl and 180 liters of water are reabsorbed by nephron segments in
humans, with urinary excretion fine tuned to meet homeostatic requirements. These tasks …

Sex differences in circadian regulation of kidney function of the mouse

AT Layton, ML Gumz - American Journal of Physiology …, 2022 - journals.physiology.org
Kidney function is regulated by the circadian clock. Not only do glomerular filtration rate and
urinary excretion oscillate during the day, but the expressions of several renal transporter …

Gender differences in cardiovascular pharmacotherapy—the example of hypertension: a mini review

J Kalibala, A Pechere-Bertschi… - Frontiers in …, 2020 - frontiersin.org
Cardiovascular disease (CVD) is the leading cause of mortality worldwide in both sexes.
Despite considerable progress in better understanding the patterns of disease in women …

Coupling of renal sodium and calcium transport: a modeling analysis of transporter inhibition and sex differences

S Hakimi, P Dutta, AT Layton - American Journal of …, 2023 - journals.physiology.org
Ca2+ transport along the nephron occurs via specific transcellular and paracellular
pathways and is coupled to the transport of other electrolytes. Notably, Na+ transport …

Adaptive changes in single-nephron GFR, tubular morphology, and transport in a pregnant rat nephron: modeling and analysis

MM Stadt, AT Layton - American Journal of Physiology …, 2022 - journals.physiology.org
Normal pregnancy is characterized by massive increases in plasma volume and electrolyte
retention. Given that the kidneys regulate homeostasis of electrolytes and volume, the organ …

Sex and circadian regulation of metabolic demands in the rat kidney: A modeling analysis

P Dutta, AT Layton - Plos one, 2024 - journals.plos.org
Renal hemodynamics, renal transporter expression levels, and urine excretion exhibit
circadian variations. Disruption of these diurnal patterns is associated with the …

Modelling female physiology from head to toe: Impact of sex hormones, menstrual cycle, and pregnancy

S Abo, D Smith, M Stadt, A Layton - Journal of theoretical biology, 2022 - Elsevier
Men and women exhibit notable differences not only in the reproductive system and
reproductive behaviors, but in many other organ and physiological systems as well. Notable …

Sex differences in renal electrolyte transport

AA McDonough, AT Layton - Current Opinion in Nephrology and …, 2023 - journals.lww.com
Sex differences in renal electrolyte transport : Current Opinion in Nephrology and Hypertension
Sex differences in renal electrolyte transport : Current Opinion in Nephrology and Hypertension …