Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence

RZ Alicic, EJ Cox, JJ Neumiller, KR Tuttle - Nature Reviews Nephrology, 2021 - nature.com
As the prevalence of diabetes continues to climb, the number of individuals living with
diabetic complications will reach an unprecedented magnitude. The emergence of new …

Diabetic macular edema: pathophysiology and novel therapeutic targets

A Das, PG McGuire, S Rangasamy - Ophthalmology, 2015 - Elsevier
Diabetic macular edema (DME) is the major cause of vision loss in diabetic persons.
Alteration of the blood–retinal barrier is the hallmark of this disease, characterized by …

The influence of lifestyle and treatment on oxidative stress and inflammation in diabetes

M Wronka, J Krzemińska, E Młynarska, J Rysz… - International Journal of …, 2022 - mdpi.com
Diabetes is considered a new pandemic of the modern world, and the number of sufferers is
steadily increasing. Sustained hyperglycemia promotes the production of free radicals and …

Drugs commonly associated with weight change: a systematic review and meta-analysis

JP Domecq, G Prutsky, A Leppin… - The Journal of …, 2015 - academic.oup.com
Context: Various drugs affect body weight as a side effect. Objective: We conducted this
systematic review and meta-analysis to summarize the evidence about commonly …

Anti-inflammatory agents in the treatment of diabetes and its vascular complications

RM Pollack, MY Donath, D LeRoith… - Diabetes care, 2016 - Am Diabetes Assoc
The association between hyperglycemia and inflammation and vascular complications in
diabetes is now well established. Antidiabetes drugs may alleviate inflammation by reducing …

Glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1: incretin actions beyond the pancreas

Y Seino, D Yabe - Journal of diabetes investigation, 2013 - Wiley Online Library
Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1)
are the two primary incretin hormones secreted from the intestine on ingestion of various …

Dipeptidyl peptidase‐4 inhibitors and cardiovascular risk: a meta‐analysis of randomized clinical trials

M Monami, B Ahrén, I Dicembrini… - Diabetes, Obesity and …, 2013 - Wiley Online Library
Aims Preliminary data from randomized trials with metabolic outcomes have shown that
treatment with dipeptidyl peptidase‐4 inhibitors (DPP4i) could be associated with a reduced …

Glucagon‐like peptide‐1 receptor agonists improve biomarkers of inflammation and oxidative stress: a systematic review and meta‐analysis of randomised controlled …

JJH Bray, H Foster‐Davies, A Salem… - Diabetes, Obesity …, 2021 - Wiley Online Library
Aim To conduct a meta‐analysis and systematic review to examine the effects of glucagon‐
like peptide‐1 receptor agonists (GLP‐1RAs) on clinical biomarkers of inflammation and …

Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives

F Ferrari, A Moretti, RF Villa - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent
neurodegenerative disorders. Despite their pathophysiological and clinical differences, they …

Exenatide exerts a potent antiinflammatory effect

A Chaudhuri, H Ghanim, M Vora, CL Sia… - The Journal of …, 2012 - academic.oup.com
Objective: Our objective was to determine whether exenatide exerts an antiinflammatory
effect. Research Design and Methods: Twenty-four patients were prospectively randomized …