Molecular imaging has experienced enormous advancements in the areas of imaging
technology, imaging probe and contrast development, and data quality, as well as machine …

The retention of infected cells in a wide variety of tissues, often with distinct viral and cellular
characteristics, underscores the importance of studying tissue reservoirs in the development …

Cell size and cell count are adaptively regulated and intimately linked to growth and
function. Yet, despite their widespread relevance, the relation between cell size and count …

Massive research efforts are now underway to develop a cure for HIV infection, allowing
patients to discontinue lifelong combination antiretroviral therapy (ART). New latency …

Purpose Sipuleucel-T, the first FDA-approved autologous cellular immunotherapy for
treatment of advanced prostate cancer, is manufactured by activating peripheral blood …

We previously demonstrated that HIV replication is concentrated in lymph node B cell
follicles during chronic infection and that HIV-specific CTL fail to accumulate in large …

The detection of viral dynamics and localization in the context of controlled HIV infection
remains a challenge and is limited to blood and biopsies. We developed a method to …

Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues
(LT s), due to the fact that the main target cell of human immunodeficiency virus (HIV) is the …

A cure for HIV infection remains elusive due to the persistence of replication-competent HIV
proviral DNA during suppressive antiretroviral therapy (ART). With the exception of rare elite …

Purpose Molecular imaging of CD4+ T cells throughout the body has implications for
monitoring autoimmune disease and immunotherapy of cancer. Given the key role of these …