Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

Decades of research have probed the interplay between chromatin (genomic DNA
associated with proteins and RNAs) and transcription by RNA polymerase (RNAP) in all …

DNA supercoiling is central to many fundamental processes of living organisms. Its average
level along the chromosome and over time reflects the dynamic equilibrium of opposite …

Chromosomes are key players of cell physiology, their dynamics provides valuable
information about its physical organization. In both prokaryotes and eukaryotes, the short …

Gene expression levels are influenced by multiple coexisting molecular mechanisms. Some
of these interactions such as those of transcription factors and promoters have been studied …

Early studies of transcriptional regulation focused on individual gene promoters defined
specific transcription factors as central agents of genetic control. However, recent genome …

Histones are a principal constituent of chromatin in eukaryotes and fundamental to our
understanding of eukaryotic gene regulation. In archaea, histones are widespread but not …

The transcriptional regulatory network (TRN) is the central pivot of a prokaryotic organism to
receive, process and respond to internal and external environmental information. However …

Mathematical modeling assists the design of synthetic regulatory networks by providing a
detailed mechanistic understanding of biological systems. Models that can predict the …

ParAB S, the most widespread bacterial DNA segregation system, is composed of a
centromeric sequence, parS, and two proteins, the ParA ATPase and the ParB DNA binding …