Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

RNAs and RNA-binding proteins can undergo spontaneous or active condensation into
phase-separated liquid-like droplets. These condensates are cellular hubs for various …

RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune
responses and have immense physiological importance. In this review, we first summarize …

RNA secondary structure plays essential roles in encoding RNA regulatory fate and function.
Most RNAs populate ensembles of alternatively paired states and are continually unfolded …

Cancer cells undergo major epigenetic alterations and transcriptomic changes, including
ectopic expression of tissue-and cell-type-specific genes. Here, we show that the germline …

DEAD-box helicases are multifunctional proteins participating in many aspects of cellular
RNA metabolism. DEAD-box helicase 41 (DDX41) in particular has pivotal roles in innate …

The life cycle of an mRNA is a complex process that is tightly regulated by interactions
between the mRNA and RNA-binding proteins, forming molecular machines known as RNA …

Determining the structure and mechanisms of all individual functional modules of cells at
high molecular detail has often been seen as equal to understanding how cells work …

DDX41 is a DEAD-box helicase and is conserved across species. Mutations in DDX41 have
been associated with myeloid neoplasms, including myelodysplastic syndrome and acute …

DDX17 is an RNA helicase shown to be involved in critical processes during the early
phases of neuronal differentiation. Globally, we compiled a case-series of 11 patients with …