Neuromelanin-sensitive MRI as a promising biomarker of catecholamine function
P Trujillo, MA Aumann, DO Claassen - Brain, 2024 - academic.oup.com
Disruptions to dopamine and noradrenergic neurotransmission are noted in several
neurodegenerative and psychiatric disorders. Neuromelanin-sensitive (NM)-MRI offers a …
neurodegenerative and psychiatric disorders. Neuromelanin-sensitive (NM)-MRI offers a …
[HTML][HTML] Brain MRI biomarkers in isolated rapid eye movement sleep behavior disorder: Where are we? A systematic review
The increasing number of MRI studies focused on prodromal Parkinson's Disease (PD)
demonstrates a strong interest in identifying early biomarkers capable of monitoring …
demonstrates a strong interest in identifying early biomarkers capable of monitoring …
[HTML][HTML] Diagnosing Parkinson's disease by combining neuromelanin and iron imaging features using an automated midbrain template approach
Background and purpose Early diagnosis of Parkinson's disease (PD) is still a clinical
challenge. Most previous studies using manual or semi-automated methods for segmenting …
challenge. Most previous studies using manual or semi-automated methods for segmenting …
[HTML][HTML] Denoising approach with deep learning-based reconstruction for neuromelanin-sensitive MRI: image quality and diagnostic performance
S Oshima, Y Fushimi, KK Miyake, S Nakajima… - Japanese Journal of …, 2023 - Springer
Abstract Purpose Neuromelanin-sensitive MRI (NM-MRI) has proven useful for diagnosing
Parkinson's disease (PD) by showing reduced signals in the substantia nigra (SN) and locus …
Parkinson's disease (PD) by showing reduced signals in the substantia nigra (SN) and locus …
Comparison of automated and manual quantification methods for n euromelanin‐sensitive MRI in Parkinson's disease
Neuromelanin‐sensitive magnetic resonance imaging quantitative analysis methods have
provided promising biomarkers that can noninvasively quantify degeneration of the …
provided promising biomarkers that can noninvasively quantify degeneration of the …
Automatic Segmentation and Quantification of Nigrosome‐1 Neuromelanin and Iron in MRI: A Candidate Biomarker for Parkinson's Disease
M Ariz, M Martínez, I Alvarez… - Journal of Magnetic …, 2023 - Wiley Online Library
Background There is a lack of automated tools for the segmentation and quantification of
neuromelanin (NM) and iron in the nigrosome‐1 (N1). Existing tools evaluate the N1 sign, ie …
neuromelanin (NM) and iron in the nigrosome‐1 (N1). Existing tools evaluate the N1 sign, ie …
[HTML][HTML] Deep learning regressor model based on nigrosome MRI in Parkinson syndrome effectively predicts striatal dopamine transporter-SPECT uptake
Purpose Nigrosome imaging using susceptibility-weighted imaging (SWI) and dopamine
transporter imaging using 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) …
transporter imaging using 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) …
[HTML][HTML] REM sleep behavior disorder: update on diagnosis and management
MA Sobreira-Neto, FG Stelzer, LLG Gitaí… - Arquivos de Neuro …, 2024 - SciELO Brasil
REM sleep behavior disorder (RBD) is characterized by a loss of atonia of skeletal muscles
during REM sleep, associated with acting out behaviors during dreams. Knowledge of this …
during REM sleep, associated with acting out behaviors during dreams. Knowledge of this …
[HTML][HTML] Regional nigral neuromelanin degeneration in asymptomatic leucine-rich repeat kinase 2 gene carrier using MRI
L Gao, R Gaurav, P Ziegner, J Ma, J Sun, J Chen… - Scientific Reports, 2024 - nature.com
Abstract Asymptomatic Leucine-Rich Repeat Kinase 2 Gene (LRRK2) carriers are at risk for
developing Parkinson's disease (PD). We studied presymptomatic substantia nigra pars …
developing Parkinson's disease (PD). We studied presymptomatic substantia nigra pars …
[HTML][HTML] Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson's disease
E Alushaj, D Hemachandra, H Ganjavi… - npj Parkinson's …, 2024 - nature.com
Idiopathic rapid eye movement sleep behaviour disorder (iRBD)—a Parkinson's disease
(PD) prodrome—might exhibit neural changes similar to those in PD. Substantia nigra pars …
(PD) prodrome—might exhibit neural changes similar to those in PD. Substantia nigra pars …