Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

WDJ Tremlett, DM Goodman, TR Steel, S Kumar… - Coordination chemistry …, 2021 - Elsevier
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

[HTML][HTML] Synthetic and natural guanidine derivatives as antitumor and antimicrobial agents: A review

AR Gomes, CL Varela, AS Pires… - Bioorganic …, 2023 - Elsevier
Guanidines are fascinating small nitrogen-rich organic compounds, which have been
frequently associated with a wide range of biological activities. This is mainly due to their …

Synthesis of palladium (II) complexes via Michael addition: antiproliferative effects through ROS-mediated mitochondrial apoptosis and docking with SARS-CoV-2

J Haribabu, S Srividya, D Mahendiran… - Inorganic …, 2020 - ACS Publications
Metal complexes have numerous applications in the current era, particularly in the field of
pharmaceutical chemistry and catalysis. A novel synthetic approach for the same is always a …

New organoruthenium (II) complexes containing N, X-donor (X= O, S) heterocyclic chelators: synthesis, spectral characterization, in vitro cytotoxicity and apoptosis …

G Kalaiarasi, MM Subarkhan, CKF Safwana… - Inorganica chimica …, 2022 - Elsevier
Four Schiff base ligands namely ((1E)-1-(1-(6-chloro-2-oxo-2H-chromen-3-yl) ethylidene)
semicarbazide)(HL 1),((1E)-1-(1-(6-chloro-2-oxo-2H-chromen-3-yl) ethylidene …

Coordination behavior of acylthiourea ligands in their Ru (II)–benzene complexes─ structures and anticancer activity

S Swaminathan, J Haribabu… - …, 2022 - ACS Publications
Acylthiourea ligands have applications in both synthetic and applied chemistry. The skeleton
of the ligand contains several heteroatoms which offer variable coordination modes in their …

An overview on the anticancer activity of Ru (II)/acylthiourea complexes

GH Ribeiro, AR Costa, AR de Souza… - Coordination Chemistry …, 2023 - Elsevier
This review outlines research on the development of ruthenium complexes containing
acylthiourea ligands with potential antitumor activity, which have been leveraged in recent …

[HTML][HTML] Effect of morphology and (Sn, Cr) doping on in vitro antiproliferation properties of hydrothermally synthesized 1D GaOOH nanostructures

R Pilliadugula, J Haribabu, MKM Subarkhan… - Journal of science …, 2021 - Elsevier
GaOOH powders of submicron dimensions were synthesized through a simple, surfactant-
free hydrothermal synthesis at pH values of 7 and 14. Sn and Cr at concentrations of 2 mol …

Novel NHC-coordinated ruthenium (II) arene complexes achieve synergistic efficacy as safe and effective anticancer therapeutics

C Chen, C Xu, T Li, S Lu, F Luo, H Wang - European journal of medicinal …, 2020 - Elsevier
There is an urgent need for more effective, less toxic cancer therapy agents. Motivated by
this need, we synthesized a small panel of N-heterocyclic carbene (NHC)-coordinated …

N-substitution in isatin thiosemicarbazones decides nuclearity of Cu (II) complexes–Spectroscopic, molecular docking and cytotoxic studies

J Haribabu, OI Alajrawy, K Jeyalakshmi… - … Acta Part A: Molecular …, 2021 - Elsevier
Abstract The mono-(1) and bi-nuclear (2) copper (II) complexes containing N-substituted
isatin thiosemicarbazone (s) were synthesized, and characterized by analytical and …

Synthesis, cytotoxicity and docking studies (with SARS-CoV-2) of water-soluble binuclear Ru-p-cymene complex holding indole thiosemicarbazone ligand

J Haribabu, N Balakrishnan, S Swaminathan… - Inorganic Chemistry …, 2021 - Elsevier
A water-soluble binuclear organometallic Ru-p-cymene complex [Ru (η 6-p-cymene)(η 2-L)]
2 (1) was prepared from (E)-2-((1H-indol-3-yl) methylene)-N-phenylhydrazine-1 …